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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(03) [March 2011] >
| Title: | Cholesterol-lowering effect of non-viscous soluble dietary fiber NUTRIOSE®6 in moderately hypercholesterolemic hamsters |
| Authors: | Juhel, Christine
Tosini, Fredéric
Steib, Marlène
Wils, Daniel
Guerin-Deremaux, Laetitia
Lairon, Denis
Cara, Louis |
| Keywords: | Cholesterol absorption
Dietary fiber
Hypercholesterolemia
Lipid
NUTRIOSE®6 |
| Issue Date: | Mar-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | NUTRIOSE®6
is a new wheat starch-based low-digestible carbohydrate. This study
investigated the effect of this soluble non-viscous fiber on cholesterol
metabolism. Hamsters fed with 0.25% cholesterol-enriched diet (CHO) were given
graded amounts of NUTRIOSE®6, i.e. 0% (cellulose, CHO), 3% (N3), 6%
(N6) or 9% (N9) (w:w). As compared to CHO diet, 9% NUTRIOSE®6
significantly lowered plasma and LDL cholesterol by 14.5 and 23.8%, respectively.
The LDL-cholesterol lowering effect was also significant with the 6% dose
(-21.4%). NUTRIOSE®6 diets prevented hepatic cholesterol
accumulation (-10 to -20%) and significantly decreased bile cholesterol (-47 to
-68%) and phospholipids (-30 to -45%) concentrations. The 9% NUTRIOSE®6
diet significantly decreased the rate of dietary cholesterol absorption (-25%)
and markedly stimulated faecal neutral sterol (+81%) and bile salts (+220%)
excretion. No significant change in cholesterol 7-a-hydroxylase or LDL-receptor
activities was observed whereas 3-hydroxy-3-methylglutaryl-coenzyme A reductase
activity was reduced by 29%. Reduced cholesterol and bile salt absorptions and
lowered cholesterol synthesis are likely mechanisms underlying the cholesterol
lowering effect of NUTRIOSE®6. Results suggest the use of NUTRIOSE®6
as a new dietary cholesterol-lowering agent that should be tested in humans as
treatment and evenly prevention of mild hypercholesterolemia. |
| Page(s): | 219-228 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(03) [March 2011]
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