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Title: | Cholesterol-lowering effect of non-viscous soluble dietary fiber NUTRIOSE®6 in moderately hypercholesterolemic hamsters |
Authors: | Juhel, Christine Tosini, Fredéric Steib, Marlène Wils, Daniel Guerin-Deremaux, Laetitia Lairon, Denis Cara, Louis |
Keywords: | Cholesterol absorption;Dietary fiber;Hypercholesterolemia;Lipid;NUTRIOSE®6 |
Issue Date: | Mar-2011 |
Publisher: | NISCAIR-CSIR, India |
Abstract: | NUTRIOSE®6 is a new wheat starch-based low-digestible carbohydrate. This study investigated the effect of this soluble non-viscous fiber on cholesterol metabolism. Hamsters fed with 0.25% cholesterol-enriched diet (CHO) were given graded amounts of NUTRIOSE®6, i.e. 0% (cellulose, CHO), 3% (N3), 6% (N6) or 9% (N9) (w:w). As compared to CHO diet, 9% NUTRIOSE®6 significantly lowered plasma and LDL cholesterol by 14.5 and 23.8%, respectively. The LDL-cholesterol lowering effect was also significant with the 6% dose (-21.4%). NUTRIOSE®6 diets prevented hepatic cholesterol accumulation (-10 to -20%) and significantly decreased bile cholesterol (-47 to -68%) and phospholipids (-30 to -45%) concentrations. The 9% NUTRIOSE®6 diet significantly decreased the rate of dietary cholesterol absorption (-25%) and markedly stimulated faecal neutral sterol (+81%) and bile salts (+220%) excretion. No significant change in cholesterol 7-a-hydroxylase or LDL-receptor activities was observed whereas 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity was reduced by 29%. Reduced cholesterol and bile salt absorptions and lowered cholesterol synthesis are likely mechanisms underlying the cholesterol lowering effect of NUTRIOSE®6. Results suggest the use of NUTRIOSE®6 as a new dietary cholesterol-lowering agent that should be tested in humans as treatment and evenly prevention of mild hypercholesterolemia. |
Page(s): | 219-228 |
URI: | http://hdl.handle.net/123456789/11118 |
ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
Appears in Collections: | IJEB Vol.49(03) [March 2011] |
Files in This Item:
File | Description | Size | Format | |
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IJEB 49(3) 219-228.pdf | 116.89 kB | Adobe PDF | View/Open |
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