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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(03) [March 2011] >
| Title: | Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation–induced behavior modification and oxidative damage in mice [RETRACTED ARTICLE] |
| Authors: | Kumar, Anil
Singh, Anant
Kumar, Puneet |
| Keywords: | Anxiety
Locomotor activity
Melatonin
Oxidative stress
Sleep deprivation |
| Issue Date: | Mar-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Sleep deprivation for 72 h caused anxiety
like behavior, weight loss, impaired locomotor activity and oxidative damage as
indicated by increase in lipid peroxidation, nitrite level and depletion of
reduced glutathione and catalase activity in sleep deprived mice brain. Treatment with melatonin (5 and 10 mg/kg,
ip) significantly improved locomotor activity, weight loss and antianxiety
effect as compared to control (sleep deprived). Biochemically, melatonin treatment significantly restored depleted reduced glutathione, catalase
activity, attenuated lipid peroxidation and nitrite level as compared to
control (72 h sleep-deprived) animals. A combination of flumazenil (0.5 mg/kg,
ip) and picrotoxin (0.5 mg/kg, ip) with lower dose of melatonin (5 mg/kg, ip)
significantly antagonized the protective effect of melatonin. However,
combination of muscimol (0.05 mg/kg, ip) with melatonin (5 mg/kg, ip) potentiated
protective effect of melatonin as compared to their effect per se. The
results suggest that melatonin may
produce its protective effect by involving GABAergic system against sleep deprivation-induced anxiety like behavior
and related oxidative damage. |
| Page(s): | 211-218 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(03) [March 2011]
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