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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(03) [March 2011] >
| Title: | Interaction of Semecarpus anacardium L. with propranolol against isoproterenol induced myocardial damage in rats |
| Authors: | Chakraborty, Manodeep
Asdaq, Syed Mohammed Basheeruddin |
| Keywords: | Cardioprotection
Electocardiographic parameters
Isoproterenol
Propranolol
Semecarpus anacardium |
| Issue Date: | Mar-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | With a view to evaluate the cardioprotective
effect of ethanolic extract of S. anacardium nut and the possible interaction with propranolol against isoproterenol
induced myocardial damage in rats, female Sprague-Dawley rats were pre-treated with propranolol (10 mg/kg
for 7 days), low and high doses of S. anacardium (100 and 500 mg/kg for 21 days) and their combination orally
and subsequently subjected to isoproterenol administration (150 mg/kg, sc) for
two consecutive days. The influence of prophylactic treatment was analysed by
quantification of biomarkers and antioxidants, electocardiographic parameters
and histopathological observations. The activities of lactate dehydrogenase and
creatinine phosphokinase-MB were reduced in serum and raised in heart tissue
with concurrent elevation in superoxide dismutase and catalase activities as
well as reduction in thiobarbituric acid reactive species levels significantly
in all treated groups compared to isoproterenol group. Similarly, electrocardiographic changes were restored
to normalcy in all treated groups. To conclude, combination of high dose
of S. anacardium with
propranolol was found to be most effective in alleviating the abnormal
conditions induced by isoproterenol. |
| Page(s): | 200-206 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(03) [March 2011]
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