18-Jun-2013
10:13:57 IST
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(03) [March 2011] >
| Title: | Effects of quinazolinones on Balb/C mice embryonic livers |
| Authors: | Lahijani, Maryam Shams
Minaei-Tehrani, Dariush
Gholipour, Hadis
Nohehkhan, Masumeh |
| Keywords: | Embryonic liver
Quinazolinones
Teratogen |
| Issue Date: | Mar-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Heterocyclic
compounds such as quinazolinones have variety of biological and pharmacological
properties (anticancer, antiinflammatory, antimicrobial, antimalaria, etc.). Effects of two new quinazolinones
viz., 4(3H)-quinazolinone-2-propyl-2-phenylethyl (QPPE)
and 4(3H)quinazolinone-2-ethyl-2-phenylethyl (QEPE) were investigated on Balb/C mice
embryos livers—the major organ of metabolism and detoxification of drugs and
toxins. Histological
and pathological studies demonstrated QPPE and QEPE as producers of toxic
metabolites after biotransformation, creating necrosis, fatty changes, increase
in the number of band cells, hepatocytes’ diameters and alkaline phosphatase,
in addition to sinusoid dilation, hemorrhages and hyperemia. Transmission
electron micrographs showed lipid droplets in
hepatocytes’ cytoplasm, necrosis, vacuolization, cytoplasm
disintegration, disfigured and swollen mitochondria,
irregular and abnormal nuclei, nuclei with heterochromatin, condensed
chromatins, myelin figures and autophages in injured hepatocytes. In conclusion, QPPE
and QEPE make toxic components after biotransformation injuring membranes and
creating inflammatory reactions. They also disturb metabolism of lipids pathways
and cause the appearances of lipid droplets in hepatocytes. |
| Page(s): | 183-190 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(03) [March 2011]
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