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Title: Evaluation of antihyperlipidemic activity of ethanolic extract of Cassia auriculata flowers
Authors: Vijayaraj, Panneer Selvam
Muthukumar, Kannan
Sabarirajan, Jayaraja
Nachiappan, Vasanthi
Keywords: Atherosclerosis;Hyperlipidemia;Triglycerides;Cholesterol;Cassia auriculata;Antihyperlipidemic activity
Issue Date: Feb-2011
Publisher: NISCAIR-CSIR, India
Abstract: Hyperlipidemia is a major risk factor for development of coronary artery disease. Cassia auriculata is traditionally used in India for medicinal purposes. In this study, effect of ethanolic extract of Cassia auriculata flowers (Et-CAF) was investigated in Triton WR1339-induced hyperlipidemic rats. Treatment with the Et-CAF (450 mg/kg b.wt) significantly reduced the total cholesterol (TC), triglycerides (TG) and low-density lipoprotein-cholesterol (LDL) levels and significantly increased the high-density lipoprotein (HDL) level associated with reduction of atherogenic index in hyperlipidemic rats. However, there was no change in the serum lipid profile of normal rats treated with Et-CAF alone. The results suggest that Et-CAF has a beneficial effect in treating hyperlipidemia and may serve as a potential drug for prevention of hyperlipidemic atherosclerosis.
Page(s): 54-58
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.48(1) [February 2011]

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