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Title: Effect of <i>Inula racemosa</i> root extract on cardiac function and oxidative stress against isoproterenol-induced myocardial infarction
Authors: Ojha, Shreesh
Bharti, Saurabh
Sharma, Ashok K
Rani, Neha
Bhatia, Jagriti
Kumari, Santosh
Arya, Dharamvir Singh
Keywords: Antioxidant
Cardiac function
Cardioprotective potential
<i style="">Inula racemosa</i>
Oxidative stress
Ventricular function
Issue Date: Feb-2011
Publisher: NISCAIR-CSIR, India
Abstract: The cardioprotective potential of <i style="">Inula racemosa</i> root hydroalcoholic extract against isoproterenol-induced myocardial infarction was investigated in rats. The rats treated with isoproterenol (85 mg/kg, s.c.) exhibited myocardial infarction, as evidenced by significant (<i>P<</i>0.05) decrease in mean arterial pressure, heart rate, contractility, relaxation along with increased left ventricular end diastolic pressure, as well as decreased endogenous myocardial enzymatic and non-enzymatic antioxidants. Isoproterenol also significantly (<i>P<</i>0.05) induced lipid peroxidation and increased leakage of myocyte injury marker enzymes. Pretreatment with <i style="">I. racemosa</i> extract (50, 100 or 200 mg/kg per day, p.o.) for 21 consecutive days, followed by isoproterenol injections on days 19<sup>th</sup> and 20<sup>th</sup> significantly (<i>P<</i>0.05) improved cardiac function by increasing the heart rate, mean arterial pressure, contractility and relaxation along with decreasing left ventricular end diastolic pressure. Pretreatment with <i style="">I.</i><i style=""> racemosa</i> also significantly (<i>P<</i>0.05) restored the reduced form of glutathione and endogenous antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase from the heart, which were depleted after isoproterenol administration. In addition to restoration of antioxidants, <i>I.</i><i> racemosa</i> significantly (<i>P<</i>0.05) inhibited lipid peroxidation and prevented the leakage of myocytes specific marker enzymes creatine phosphokinase-MB and lactate dehydrogenase from the heart. Thus, it is concluded that <i style="">I.</i><i style=""> racemosa</i> protects heart from isoproterenol-induced myocardial injury by reducing oxidative stress and modulating hemodynamic and ventricular functions of the heart. Present study findings demonstrate the cardioprotective effect of <i style="">I.</i><i style=""> racemosa</i> and support the pharmacological relevance of its use and cardioprotection mechanism in ischemic heart disease as well as substantiate its traditional claim
Description: 22-28
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.48(1) [February 2011]

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