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Title: MsbA ATP-binding cassette (ABC) transporter of E. coli: Structure and possible flippase mechanism
Authors: Kaul, Gautam
Pattan, Gurulingappa
Keywords: Structure
MsbA
ATP-binding cassette transporter
ATP hydrolysis
Flip-flop
E. coli
Issue Date: Feb-2011
Publisher: NISCAIR-CSIR, India
Abstract: ATP-binding cassette (ABC) transporters utilize the energy present in cellular ATP to drive the translocation of structurally diverse set of solutes across the membrane barriers of eubacteria, archaebacteria and eukaryotes. In bacteria, these transporters are considered to be important virulence factors because they play role in nutrient uptake and in the secretion of toxins. The advances in structural determination and functional analysis of bacterial transporters have greatly increased our understanding of the mechanism of transport of these ABC transporters. Although progress in the field of structural biology has been made with the prokaryotic family members, it is likely that eukaryotic transporters will utilize the same mechanisms for translocation process. In this review, we summarize the function of the known MsbA ABC transporters in E. coli and mechanistic insights from structural and possible flippase mechanism studies.
Page(s): 7-13
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Source:IJBB Vol.48(1) [February 2011]

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