|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.48 [2011] >
IJBB Vol.48(1) [February 2011] >
| Title: | MsbA ATP-binding cassette (ABC) transporter of E. coli: Structure and possible flippase mechanism |
| Authors: | Kaul, Gautam
Pattan, Gurulingappa |
| Keywords: | Structure
MsbA
ATP-binding cassette transporter
ATP hydrolysis
Flip-flop
E. coli |
| Issue Date: | Feb-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | ATP-binding cassette (ABC) transporters
utilize the energy present in cellular ATP to drive the translocation of
structurally diverse set of solutes across the membrane barriers of eubacteria,
archaebacteria and eukaryotes. In bacteria, these transporters are considered
to be important virulence factors because they play role in nutrient uptake and
in the secretion of toxins. The advances in structural determination and
functional analysis of bacterial transporters have greatly increased our
understanding of the mechanism of transport of these ABC transporters. Although
progress in the field of structural biology has been made with the prokaryotic
family members, it is likely that eukaryotic transporters will utilize the same
mechanisms for translocation process. In this review, we summarize the function
of the known MsbA ABC transporters in E.
coli and mechanistic insights from structural and possible flippase
mechanism studies. |
| Page(s): | 7-13 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.48(1) [February 2011]
|
|
