23-May-2013
13:58:15 IST
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(02) [February 2011] >
| Title: | Synthesis and antimicrobial activity of bis-[2-imino-3-[5-(3-methylbenzo[b]furan-7-yl)-1,3,4-thiadiazol-2-yl]-5-(arylidene)-1,3-thiazolan-4-one]methanes |
| Authors: | Reddy, Ch Sanjeeva
Rao, D Chandrashekar
Yakub, V
Nagaraj, A |
| Keywords: | Bis-thiadiazolyl-thiazolan-4-one
Antibacterial activity
Antifungal activity |
| Issue Date: | Feb-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of novel bis-[2-imino-3-[5-(3-methylbenzo[b]furan-7-yl)-1,3,4-thiadiazol-2-yl]-5-(arylidene)-1,3-thiazolan-4-one]meth-
anes 6a-j have been prepared and their structures confirmed by
IR, NMR, MS and elemental analyses. All the synthesized compounds have been
tested for their antimicrobial activity against Gram-positive and Gram-negative
bacteria, and fungi. Among the synthesized compounds, 6c, 6e, 6f
and 6g are found to be the most
active against Bacillus subtilis, Bacillus sphaericus, Staphylococcus aureus, Klebsiella aerogenes and Chromobacterium violaceum. Similarly,
these compounds show potent antifungal effect against Candida albicans, Aspergillus
fumigatus, Trichophyton rubrum,
and Trichophyton mentagrophytes. |
| Page(s): | 253-259 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(02) [February 2011]
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