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IJC-B Vol.50B(02) [February 2011] >


Title: Synthesis and antimicrobial activity of bis-[2-imino-3-[5-(3-methylbenzo[b]furan-7-yl)-1,3,4-thiadiazol-2-yl]-5-(arylidene)-1,3-thiazolan-4-one]methanes
Authors: Reddy, Ch Sanjeeva
Rao, D Chandrashekar
Yakub, V
Nagaraj, A
Keywords: Bis-thiadiazolyl-thiazolan-4-one
Antibacterial activity
Antifungal activity
Issue Date: Feb-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of novel bis-[2-imino-3-[5-(3-methylbenzo[b]furan-7-yl)-1,3,4-thiadiazol-2-yl]-5-(arylidene)-1,3-thiazolan-4-one]­me­th- anes 6a-j have been prepared and their structures confirmed by IR, NMR, MS and elemental analyses. All the synthesized compounds have been tested for their antimicrobial activity against Gram-positive and Gram-negative bacteria, and fungi. Among the synthesized compounds, 6c, 6e, 6f and 6g are found to be the most active against Bacillus subtilis, Bacillus sphaericus, Staphylococcus aureus, Klebsiella aerogenes and Chromo­bacterium violaceum. Similarly, these compounds show potent antifungal effect against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes.
Page(s): 253-259
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(02) [February 2011]

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