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|Title:||Synthesis and antimicrobial activity of 1-(5-methyl-3-isoxazolyl)-3,6-diaryl-4-thioxo-1,3,5-triazinan-2-ones|
Reddy, M Nagi
Reddy, K Govardhan
|Keywords:||Schiff bases;N-isoxazolyl- -amino isothiocyanates;Cyclization;Isoxazolyl-4-thioxo-1,3,5-triazinan-2-ones|
|Abstract:||Treatment of 3-benzalamino-5-methylisoxazoles 1 with ammonium thiocyanate in hot acetic acid affords the corresponding N-isothiocyanato(phenyl)methyl-N-(5-methyl-3-isoxazolyl)amines 2a-j in excellent yields. N-Isoxazolyl-α-aminoisothiocyanates 2a-j on reaction with aryl isocyanates undergoes cyclization to give the corresponding isoxazolyl-4-thioxo-1,3,5-triazinan-2-ones 3a-l in good yields. The compounds 2a-j and 3a-l have been screened for their antimicrobial activity.|
|Appears in Collections:||IJC-B Vol.50B(02) [February 2011]|
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