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IJC-B Vol.50B(02) [February 2011] >


Title: Synthesis of novel 3, 5-disubstituted-4,5-dihydroisoxazoles and 3,4,5-trisubstituted isoxazoles and their biological activity
Authors: Shailaja, M
Manjula, A
Rao, B Vittal
Keywords: 1,3-Dipolar cycloaddition
Chloramine-T
Dihydroisoxazoles
Isoxazoles
Halopyridines
,-unsaturated ketones
Issue Date: Feb-2011
Publisher: NISCAIR-CSIR, India
Abstract: 1,3-Dipolar cycloaddition of nitrile oxide generated from substituted pyridinyloxy benzaldoximes with styrene or ,-unsaturated ketones produces a series of 3,5-disubstituted-4,5-dihydroisoxazoles and 3,4,5-trisubstituted isoxazoles. On the other hand, C-chlorooxime reacts with ,-unsaturated ketones yielding 3,4,5-trisubstituted isoxazoles. All the compounds are evaluated for their antimicrobial and antifungal activity and action on isolated frog heart. Aldoxime derivatives 2e, 2f have been found to show good inhibitiory activity where as compounds 4g, 4h show better inhibition of sodium calcium exchange ion on isolated frog heart studies.
Page(s): 214-222
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(02) [February 2011]

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