Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/11030
Title: Synthesis of novel 3, 5-disubstituted-4,5-dihydroisoxazoles and 3,4,5-trisubstituted isoxazoles and their biological activity
Authors: Shailaja, M
Manjula, A
Rao, B Vittal
Keywords: 1,3-Dipolar cycloaddition
Chloramine-T
Dihydroisoxazoles
Isoxazoles
Halopyridines
<img src='/image/spc_char/alpha.gif' border=0> ,<img src='/image/spc_char/beta.gif' border=0>-unsaturated ketones
Issue Date: Feb-2011
Publisher: NISCAIR-CSIR, India
Abstract: 1,3-Dipolar cycloaddition of nitrile oxide generated from substituted pyridinyloxy benzaldoximes with styrene or <img src='/image/spc_char/alpha.gif' border=0>,<img src='/image/spc_char/beta.gif' border=0>-unsaturated ketones produces a series of 3,5-disubstituted-4,5-dihydroisoxazoles and 3,4,5-trisubstituted isoxazoles. On the other hand, C-chlorooxime reacts with <img src='/image/spc_char/alpha.gif' border=0> ,<img src='/image/spc_char/beta.gif' border=0>-unsaturated ketones yielding 3,4,5-trisubstituted isoxazoles. All the compounds are evaluated for their antimicrobial and antifungal activity and action on isolated frog heart. Aldoxime derivatives <b style="">2e</b>, <b style="">2f</b> have been found to show good inhibitiory activity where as compounds <b style="">4g</b>,<b style=""> 4h</b> show better inhibition of sodium calcium exchange ion on isolated frog heart studies.
Description: 214-222
URI: http://hdl.handle.net/123456789/11030
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(02) [February 2011]

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