NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(02) [February 2011] >

Title: Synthesis of novel 3, 5-disubstituted-4,5-dihydroisoxazoles and 3,4,5-trisubstituted isoxazoles and their biological activity
Authors: Shailaja, M
Manjula, A
Rao, B Vittal
Keywords: 1,3-Dipolar cycloaddition
,-unsaturated ketones
Issue Date: Feb-2011
Publisher: NISCAIR-CSIR, India
Abstract: 1,3-Dipolar cycloaddition of nitrile oxide generated from substituted pyridinyloxy benzaldoximes with styrene or ,-unsaturated ketones produces a series of 3,5-disubstituted-4,5-dihydroisoxazoles and 3,4,5-trisubstituted isoxazoles. On the other hand, C-chlorooxime reacts with ,-unsaturated ketones yielding 3,4,5-trisubstituted isoxazoles. All the compounds are evaluated for their antimicrobial and antifungal activity and action on isolated frog heart. Aldoxime derivatives 2e, 2f have been found to show good inhibitiory activity where as compounds 4g, 4h show better inhibition of sodium calcium exchange ion on isolated frog heart studies.
Page(s): 214-222
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(02) [February 2011]

Files in This Item:

File Description SizeFormat
IJCB 50B(2) 214-222.pdf134.07 kBAdobe PDFView/Open
 Current Page Visits: 120 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 165511 since 01-Sep-2015  Last updated on 27-Jun-2016Webmaster: