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|Title:||Synthesis of novel 3, 5-disubstituted-4,5-dihydroisoxazoles and 3,4,5-trisubstituted isoxazoles and their biological activity|
Rao, B Vittal
|Abstract:||1,3-Dipolar cycloaddition of nitrile oxide generated from substituted pyridinyloxy benzaldoximes with styrene or ,-unsaturated ketones produces a series of 3,5-disubstituted-4,5-dihydroisoxazoles and 3,4,5-trisubstituted isoxazoles. On the other hand, C-chlorooxime reacts with ,-unsaturated ketones yielding 3,4,5-trisubstituted isoxazoles. All the compounds are evaluated for their antimicrobial and antifungal activity and action on isolated frog heart. Aldoxime derivatives 2e, 2f have been found to show good inhibitiory activity where as compounds 4g, 4h show better inhibition of sodium calcium exchange ion on isolated frog heart studies.|
|Appears in Collections:||IJC-B Vol.50B(02) [February 2011]|
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