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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(02) [February 2011] >
| Title: | Synthesis of novel 3, 5-disubstituted-4,5-dihydroisoxazoles and 3,4,5-trisubstituted isoxazoles and their biological activity |
| Authors: | Shailaja, M
Manjula, A
Rao, B Vittal |
| Keywords: | 1,3-Dipolar cycloaddition
Chloramine-T
Dihydroisoxazoles
Isoxazoles
Halopyridines
 , -unsaturated ketones |
| Issue Date: | Feb-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 1,3-Dipolar cycloaddition of nitrile oxide
generated from substituted pyridinyloxy benzaldoximes with styrene or
,-unsaturated ketones produces a series of
3,5-disubstituted-4,5-dihydroisoxazoles and 3,4,5-trisubstituted isoxazoles. On
the other hand, C-chlorooxime reacts with ,-unsaturated ketones yielding
3,4,5-trisubstituted isoxazoles. All the compounds are evaluated for their
antimicrobial and antifungal activity and action on isolated frog heart.
Aldoxime derivatives 2e, 2f
have been found to show good inhibitiory activity where as compounds 4g,
4h show better inhibition of sodium calcium exchange ion on isolated frog
heart studies. |
| Page(s): | 214-222 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(02) [February 2011]
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