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Title: Synthesis and <i style="">in vitro</i> antibacterial activity of <i style="">N</i>-alkyl and <i style="">N</i>-aryl piperazine derivatives
Authors: Singh, Krishna K
Joshi, Subhash C
Mathela, Chandra S
Keywords: <i style="">N</i>-Methyl piperazine
<i style="">N</i>-phenyl piperazine
<i style="">N</i>-benzyl piperazine
Antibacterial activity
Issue Date: Feb-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of <i style="">N</i>-alkyl and <i style="">N</i>-aryl<b style=""> </b>substituted piperazine derivatives have been synthesized in order to evaluate their antibacterial activity against four Gram-positive (<i style="">Streptococcus mutans</i> MTCC 890, <i style="">Staphylococcus aureus</i> MTCC 96, <i style="">Bacillus subtilis</i> MTCC 121, <i style="">Staphylococcus epidermidis</i> MTCC 435) and one Gram-negative (<i style="">Escherichia coli</i> MTCC 723) bacteria by disc diffusion and microbroth dilution methods. These compounds have been characterized by their MS, IR, <sup>1</sup>H and <sup>13</sup>C NMR spectral data. The benzyl piperazine derivatives 2-(4-benzylpiperazin-1-yl)-1-<i style="">p</i>-tolylethanone¬† and<b style=""> </b>2-(4-benzylpiperazin-1-yl)-1-(4-methoxyphenyl) ethanone show remarkable antibacterial activity even at low concentration against <i style="">S. epidermidis</i>, <i style="">S. mutans</i> and<i style=""> B. subtilis </i>bacterial strains and are even close to the standard antibiotic, ampicillin. Furthermore, benzyl substitution increases antibacterial activity as compared to methyl and phenyl substituents under identical conditions.
Description: 196-200
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(02) [February 2011]

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