NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(02) [February 2011] >


Title: Synthesis and in vitro antibacterial activity of N-alkyl and N-aryl piperazine derivatives
Authors: Singh, Krishna K
Joshi, Subhash C
Mathela, Chandra S
Keywords: N-Methyl piperazine
N-phenyl piperazine
N-benzyl piperazine
Antibacterial activity
Issue Date: Feb-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of N-alkyl and N-aryl substituted piperazine derivatives have been synthesized in order to evaluate their antibacterial activity against four Gram-positive (Streptococcus mutans MTCC 890, Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 121, Staphylococcus epidermidis MTCC 435) and one Gram-negative (Escherichia coli MTCC 723) bacteria by disc diffusion and microbroth dilution methods. These compounds have been characterized by their MS, IR, 1H and 13C NMR spectral data. The benzyl piperazine derivatives 2-(4-benzylpiperazin-1-yl)-1-p-tolylethanone¬† and 2-(4-benzylpiperazin-1-yl)-1-(4-methoxyphenyl) ethanone show remarkable antibacterial activity even at low concentration against S. epidermidis, S. mutans and B. subtilis bacterial strains and are even close to the standard antibiotic, ampicillin. Furthermore, benzyl substitution increases antibacterial activity as compared to methyl and phenyl substituents under identical conditions.
Page(s): 196-200
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(02) [February 2011]

Files in This Item:

File Description SizeFormat
IJCB 50B(2) 196-200.pdf79.88 kBAdobe PDFView/Open
 Current Page Visits: 937 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 624324 since 06-Feb-2009  Last updated on 13-Nov-2014Webmaster: nopr@niscair.res.in