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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(02) [February 2011] >
| Title: | Acute and sub-acute toxicity of ethanolic extract of Canthium mannii Hiern stem bark on Mus musculus |
| Authors: | Poné, J Wabo
Mbida, Mpoame
Bilong, C F Bilong |
| Keywords: | Canthium mannii
Stem-bark extract
Toxicity |
| Issue Date: | Feb-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Acute and sub-acute
toxicity of ethanolic extract (ETE) of C. mannii was assessed on white
mice (Mus musculus). After 48 h
of extract administration, no death was registered. It was deduced that
the LD50 was indisputably higher than 16 g/kg body weight. The
sub-acute toxicity test was based on the daily administration of three doses of
ETE (300, 600 and 1200 mg/kg body weight) for four weeks; 1% DMSO served as
negative control. As for the first experiment, no sign of toxicity was
registered. Conversely, the sub acute doses stimulated and increased the
weight-rate of mice after 7 days of treatment. Except for the spleen weight,
the doses administrated did not modify the weight index. It was observed that,
sub-acute doses induced and increased (a) the food (particularly) and water
consumption according to time and (b) the number of red and white blood cells.
It was thought that, ETE can stimulate the haematopoietic function. Finally, no
time variation of the activity of alanine aminotransferase and aspartate
aminotransferase enzyme was observed in the serum of euthanized mice. The
results showed the innocuity of ETE of C. mannii and thus validated his utilization in cameroonian
traditional pharmacopoea. |
| Page(s): | 146-150 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(02) [February 2011]
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