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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(02) [February 2011] >
| Title: | Human sodium iodide symporter (hNIS) in fibroadenoma breast—A immunohistochemical study |
| Authors: | Rai, Ruchi
Shrivastava, Ashutosh
Tandon, Ashwani
Godbole, Madan M
Kumar, Sandeep
Das, Vinita
Dwivedi, Varsha
Pal, Lily |
| Keywords: | Fibroadenoma breast
Human sodium iodide symporter (hNIS)
Immunohistochemistry |
| Issue Date: | Feb-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Human sodium iodide symporter
(hNIS), responsible for the active transport of iodine is an integral plasma
membrane glycoprotein present in the thyroid cells and extrathyroid tissues
like breast and salivary glands. If its functional form is unequivocally shown
in benign or malignant breast tissues, then it may serve as a basis for
diagnosis and treatment using radioactive iodine. With an aim to analyze the
hNIS expression in a distinct benign breast condition of fibroadenoma, biopsy proven fibroadenoma tissues, normal non-lactating breast tissue and
biopsy proven infiltrating duct carcinoma tissues were examined for hNIS
expression using immunohistochemistry. Out of 20 biopsy proven
fibroadenoma tissues, 19 (95%) showed positivity for hNIS protein and only one was negative. Of these 10% were mildly
positive, 50% cases were moderately positive and 35% showed intense positivity.
None of the control tissue obtained from reduction mammoplasty specimens or
normal breast tissues samples (5 cms away from the tumor) were positive. hNIS was also intensely positive in 9 out of 10 (90%) infiltrating duct
carcinoma tissues and moderately positive in one case. These preliminary
results show that hNIS was present in high frequency as demonstrated by
immunohistochemistry in fibroadenoma breast. |
| Page(s): | 113-117 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(02) [February 2011]
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