NISCAIR Online Periodicals Repository

Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.70 [2011] >
JSIR Vol.70(02) [February 2011] >

Title: Tablet disintegrant activities of new starch from immature pepino fruits
Authors: Khan, Saleemulla
Ramu, G
Mohan, G Krishna
Jayaveera, K N
Bhalgat, Chetan
Keywords: Paracetamol
Solanum muricatum
Starch and Disintegrant
Maize Starch
Issue Date: Feb-2011
Publisher: NISCAIR-CSIR, India
Abstract: A new starch powder isolated by steeping process from pepino fruits (Solanum muricatum Aiton) as tablet disintegrant was compared with maize starch BP (MS) in paracetamol tablets prepared via wet granulation method. Increasing concentration resulted in slight increase in hardness and decrease in friability for MS, whereas hardness slightly decreased and friability marginally increased for PS. PS absorbed least moisture followed by MS. PS formulations showed longer disintegration time than MS. However disintegration time was comparable at 10% w/w concentration: PS, 4.7; and MS, 5.0 min. PS is likely to initiate disintegration by swelling and capillary action. Drug dissolution (70%) was within 30 min. Thus PS powder appears to be a suitable substitute for MS as internal disintegrant in paracetamol tablet formulations.
Page(s): 149-155
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.70(02) [February 2011]

Files in This Item:

File Description SizeFormat
JSIR 70(2) 149-155.pdf313.04 kBAdobe PDFView/Open
 Current Page Visits: 183 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 172464 since 01-Sep-2015  Last updated on 30-Jun-2016Webmaster: