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Title: Production of ganoderic acid by Ganoderma lucidium MTCC 1039 from cottonseed oil cake: Statistical screening of process variables
Authors: Baskar, G
Rajesh, L K Shree
Pavithra, S K
Aarathi, S
Renganathan, S
Keywords: Ganoderic acid;Pareto chart;Plackett-Burman design;process variables;submerged fermentation
Issue Date: Jan-2011
Publisher: NISCAIR-CSIR, India
Abstract: Production of ganoderic acid (GA) using submerged fermentation has received great attention in recent years for its increased demand in the treatment of hepatitis-B and to reduce blood pressure, blood cholesterol and platelet aggregation. Present study aims to produce GA by Ganoderma lucidium MTCC 1039 from cottonseed oil cake and to identify the important media components and operating conditions. The effect of variables, such as cottonseed oil cake, glucose, ammonium chloride, di-sodium hydrogen phosphate, sodium di-hydrogen phosphate, magnesium sulfate, pH and inoculums size was studied using two level Plackett-Burman design. The experimental GA production was subjected to statistical analysis using MINITAB 15 and statistical significance of the variables was analyzed. The first order linear model showing the effect of variables on GA production was validated with regression coefficient (R2) 0.92 and normal probability plot. The statistical significance of the variables was studied using student’s t-test and pareto chart. It was found out that the cottonseed oil cake and ammonium chloride are the highly significant and glucose and magnesium sulfate are the most important factors on the production of GA by G.  lucidium MTCC 1039.
Page(s): 65-69
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.10(1) [January 2011]

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