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Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.10 [2011] >
IJBT Vol.10(1) [January 2011] >
| Title: | Production of ganoderic acid by Ganoderma lucidium MTCC 1039 from cottonseed oil cake: Statistical screening of process variables |
| Authors: | Baskar, G
Rajesh, L K Shree
Pavithra, S K
Aarathi, S
Renganathan, S |
| Keywords: | Ganoderic acid
Pareto chart
Plackett-Burman design
process variables
submerged fermentation |
| Issue Date: | Jan-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Production of ganoderic acid (GA) using submerged
fermentation has received great attention in recent years for its increased
demand in the treatment of
hepatitis-B and to reduce blood pressure, blood cholesterol and platelet
aggregation. Present study aims to produce GA by Ganoderma lucidium MTCC 1039 from
cottonseed oil cake and to identify the important media components and
operating conditions. The
effect of variables, such as cottonseed oil cake, glucose, ammonium chloride,
di-sodium hydrogen phosphate, sodium di-hydrogen phosphate, magnesium sulfate, pH and inoculums size was studied using
two level Plackett-Burman design. The experimental GA production was subjected to
statistical analysis using MINITAB 15 and statistical significance of the
variables was analyzed. The first order linear model showing the effect of
variables on GA production was validated with regression coefficient (R2)
0.92 and normal probability plot. The statistical significance of the variables
was studied using student’s t-test and pareto chart. It was found out that the
cottonseed oil cake and ammonium chloride are the highly significant and glucose
and magnesium sulfate are the most important factors on the production
of GA by G. lucidium MTCC 1039. |
| Page(s): | 65-69 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.10(1) [January 2011]
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