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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(01) [January 2011] >
| Title: | Synthesis of 4-(3H)-quinazolinones by microwave assisted tandem reaction and evaluation of their antibacterial and antifungal activities |
| Authors: | Priya, M Gnana Ruba
Zulykama, Y
Girija, K
Murugesh, S
Perumal, P T |
| Keywords: | Quinazolinones
Vilsmeir reaction
microwave
antibacterial
antifungal |
| Issue Date: | Jan-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A one-pot synthesis
of quinazolinone derivatives from the reaction of anthranilic acid and primary
aromatic amines with Vilsmeier reagent (DMF/POCl3) has been carried
out. The reaction occurred in a few minutes under microwave irradiation
providing good yields. All the synthesized compounds have been screened for their
in vitro antibacterial activity
against S. aureus, S. epidermis, B. cereus, B. subtilis, Ps. aureus, Kl. pneumonia and E. coli
and antifungal activity against A. niger
and C. albicans. Their minimal
inhibitory concentration (MIC) values range between 25-100 µg/mL. The screening
data indicates that the compounds 3c,
3e, 3g and 3i have promising
anti-bacterial activity and compounds 3b,
3c and 3h have promising
antifungal activity. |
| Page(s): | 98-102 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(01) [January 2011]
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