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Title: Conventional as well as microwave assisted synthesis and antimicrobial screening of 4-aryl-3-chloro-1-[(5-nitroindazol-1-yl) acetamido]-2-oxo-azetidines
Authors: Upadhyay, Apoorva
Srivastava, S K
Srivastava, S D
Yadav, R
Keywords: 5-Nitroindazole
conventional and microwave synthesis
antimicrobial agents
Issue Date: Jan-2011
Publisher: NISCAIR-CSIR, India
Abstract: Several new 4-aryl-3-chloro-1-[(5-nitroindazol-1-yl) acetamido]-2-oxo-azetidines<b style=""> 4a-l</b> have been synthesized from 2-(5-nitroindazol-1-yl) acetamidyl amino arylidenes <b style="">3a-l</b>. The reactions have been carried out by both conventional as well as microwave method. The structures of all these compounds are confirmed by IR, <sup>1</sup>H and <sup>13</sup>C&nbsp;NMR, FAB-mass spectra and also by microanalytical data. All the synthesized compounds have been screened for their antibacterial activity against <i style="">Escherichia coli, Bacillus subtilis </i>and <i style="">Salmonella typhi </i>and antifungal activity against <i style="">Aspergillus flavus, Penicillium citrinum and Fusarium oxysporum. </i>Some of the synthesized compounds exhibit significant antibacterial and antifungal activities.
Description: 89-97
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(01) [January 2011]

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