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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.47 [2010] >
IJBB Vol.47(6) [December 2010] >
| Title: | Cadmium-induced oxidative stress in Saccharomyces cerevisiae |
| Authors: | Muthukumar, Kannan
Nachiappan, Vasanthi |
| Keywords: | Cadmium
Superoxide dismutase
Catalase
Glutathione
Glutathione peroxidase
Saccharomyces cerevisiae |
| Issue Date: | Dec-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The
present study was undertaken to determine the effect of cadmium (Cd) on the
antioxidant status of the yeast Saccharomyces
cerevisiae. S. cerevisiae serves
as a good eukaryotic model system for the study of the molecular mechanisms of
oxidative stress. We investigated the adaptative response of S. cerevisiae exposed to Cd. Yeast cells
could tolerate up to 100 μM Cd and an inhibition in the growth and viability
was observed. Exposure of yeast cells to Cd showed an increase in malondialdehyde and glutathione. The activities of catalase,
superoxide dismutase and glutathione peroxidase were also high in Cd-exposed
cells. The incorporation of Cd led to significant increase in iron, zinc and
inversely the calcium, copper levels were reduced. The results suggest that
antioxidants were increased and are involved in the protection against
macromolecular damage during oxidative stress; presumably, these enzymes are
essential for counteracting the pro-oxidant effects of Cd. |
| Page(s): | 383-387 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.47(6) [December 2010]
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