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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.47 [2010] >
IJBB Vol.47(6) [December 2010] >
| Title: | Determination of oxidant stress in plasma of rheumatoid arthritis and primary osteoarthritis patients |
| Authors: | Tetik, Sermin
Ahmad, Sarfraz
Alturfan, A Ata
Fresko, Izzet
Disbudak, Murat
Sahin, Yucel
Aksoy, Halil
Yardimci, K Turay |
| Keywords: | Oxidative stress
Inflammation
Rheumatoid arthritis
Primary osteoarthritis
Biochemical markers |
| Issue Date: | Dec-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Determination of oxidant stress in plasma of
rheumatoid arthritis (RA) and primary osteoarthritis (POA) patients is
important in understanding the pathogenesis of these diseases. In this study,
we examined the relationship between oxidant stress and inflammation by
measuring protein carbonyl content, thiol levels and plasma protein fractions
as the oxidation markers and erythrocyte sedimentation rate (ESR), C-reactive protein
(CRP) tests as inflammation markers. Protein carbonyls content was higher in RA
and POA patients, as compared to controls (p<0.0001),
while the plasma thiol levels in both groups of patients were significantly
lower than controls (p<0.0001).
Increased levels of proteins under 40 kDa molecular mass were detected in the
RA and POA patients compared to that of controls (p<0.0001) both in HPLC and SDS-PAGE analysis. Total protein
concentration in plasma of RA patients was higher than the controls (p<0.001), while in POA patients was
lower than that of controls (p<0.001).
ESR and CRP levels were higher in both the patient groups than the normal group
(p<0.001). These results suggested
that alterations in the oxidant stress markers could be the cause of inflammation
in these diseases. Thus, while working for RA/POA treatment strategies,
consideration of the relationship between oxidant stress and inflammation would
be worth evaluating. |
| Page(s): | 353-358 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.47(6) [December 2010]
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