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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.1 [2010] >
IJNPR Vol.1(4) [December 2010] >
| Title: | Immunostimulatory activity of aqueous extract of Murraya koenigii (Linn.) Spreng. leaves |
| Authors: | Shah, A S
Juvekar, A R |
| Keywords: | Antibody titre
Hypersensitivity
Immunomodulatory
Iimmunostimulatory
Curry patta
Murraya koenigii
Myelosuppression
Nitric oxide |
| Issue Date: | Dec-2010 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl.8 - A61K 36/00, A61K 36/75, A61K 127/00, A61P 37/00 |
| Abstract: | Leaves of Murraya
koenigii (Linn.) Spreng. (Curry
patta) are reported to possess antidiabetic, antimicrobial, cytotoxic and
anti-inflammatory activity. In the present study immunomodulatory potential of
aqueous extract of its leaves on specific (humoral and cell mediated) and non
specific (macrophage) immunity in mice was investigated. Oral administration of the
aqueous extract of leaves at the doses of 250 and 500 mg/kg significantly
enhanced the delayed-type hypersensitivity reaction induced by ovalbumin
however, the effect was not dose related. The extract also potentiated the
production of circulating antibody titre significantly in response to
ovalbumin. Pre-treatment of the extract restored the myelosuppressive effect of
cyclophosphamide through ameliorating total white blood cells count.
Significant increase in release of nitric oxide from mouse peritoneal
macrophages in culture supernatant indicates enhancement of cytotoxic activity
of macrophages. The present investigation thus reveals that aqueous extract of M. koenigii leaves possesses immunostimulatory activity by acting
on both specific and non-specific immunity. |
| Page(s): | 450-455 |
| CC License: |  CC Attribution- Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJNPR Vol.1(4) [December 2010]
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