Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/10818
Title: Protective effect of aqueous extract of <i>Moringa oleifera</i> Lam. stem bark on serum lipids, marker enzymes and heart antioxidants parameters in isoproterenol-induced cardiotoxicity in Wistar rats
Authors: Gunjal, Mahendra A
Shah, Abhishek S
Wakade, Alok S
Juvekar, Archana R
Keywords: <i>Moringa oleifera</i>
Drumstick tree
Isoproterenol
Marker enzymes
Antioxidant enzymes
Cardioprotection
Hypolipidemic
Issue Date: Dec-2010
Publisher: NISCAIR-CSIR, India
Series/Report no.: <b style="">Int. cl.<sup>8</sup>—</b>A61K 36/00, A61P 9/00, A61P 17/18
Abstract: Cardio protective potential of aqueous extract of <i style="">Moringa </i><i style="">oleifera</i> Lam. (Family-Moringaceae) stem bark on serum lipids profiles, myocardial marker enzymes in serum and heart homogenate, antioxidant parameters in heart homogenate and histopathological findings in isoproterenol (ISO)-induced cardiotoxicity in rats was evaluated. Subcutaneous injection of ISO (85 mg/kg) to Wistar rats showed a significant (<i style="">P</i><0.05) increase in the levels of thiobarbituric acid reactive substances along with a significant decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-<i>S</i>-transferase, glutathione reductase and reduced glutathione in the heart. It also significantly increased the level of cholesterol, triglycerides, VLDL and LDL with significant decrease in the level of HDL, increased the level of myocardial marker enzymes CK, LDH, ALT and AST in serum and concomitantly decreased in heart. Oral administration of aqueous extract of <i style="">M. </i><i style="">oleifera</i> (250 and 500 mg/kg) to ISO-induced rats daily for a period of 21 days showed a significant improvement in lipid profile along with marker enzymes in serum and heart homogenate. It also decreased the levels of thiobarbituric acid reactive substances and improved antioxidant status by increasing the activities of antioxidant enzymes. Histopathological findings of the myocardial tissue showed the protective role of <i style="">M. oleifera</i> in ISO-induced cardiotoxicity in rats. The effect at 500 mg/kg dose was more pronounced.
Description: 485-492
URI: http://hdl.handle.net/123456789/10818
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJNPR Vol.1(4) [December 2010]

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