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Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.1 [2010] >
IJNPR Vol.1(4) [December 2010] >
| Title: | Protective effect of aqueous extract of Moringa oleifera Lam. stem bark on serum lipids, marker enzymes and heart antioxidants parameters in isoproterenol-induced cardiotoxicity in Wistar rats |
| Authors: | Gunjal, Mahendra A
Shah, Abhishek S
Wakade, Alok S
Juvekar, Archana R |
| Keywords: | Moringa oleifera
Drumstick tree
Isoproterenol
Marker enzymes
Antioxidant enzymes
Cardioprotection
Hypolipidemic |
| Issue Date: | Dec-2010 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl.8—A61K 36/00, A61P 9/00, A61P 17/18 |
| Abstract: | Cardio protective potential of aqueous extract of Moringa oleifera Lam. (Family-Moringaceae) stem bark on serum
lipids profiles, myocardial marker enzymes in serum and heart homogenate,
antioxidant parameters in heart homogenate and histopathological findings in
isoproterenol (ISO)-induced cardiotoxicity in rats was evaluated. Subcutaneous
injection of ISO (85 mg/kg) to Wistar rats showed a significant (P<0.05) increase in the levels of
thiobarbituric acid reactive substances along with a significant decrease in
the activities of superoxide dismutase, catalase, glutathione peroxidase,
glutathione-S-transferase, glutathione reductase and reduced glutathione
in the heart. It also significantly increased the level of cholesterol,
triglycerides, VLDL and LDL with significant decrease in the level of HDL,
increased the level of myocardial marker enzymes CK, LDH, ALT and AST in serum
and concomitantly decreased in heart. Oral administration of aqueous extract of M. oleifera (250
and 500 mg/kg) to ISO-induced rats daily for a period
of 21 days showed a significant improvement in lipid profile along with marker
enzymes in serum and heart homogenate. It also decreased the levels of
thiobarbituric acid reactive substances and improved antioxidant status by
increasing the activities of antioxidant enzymes. Histopathological findings of
the myocardial tissue showed the protective role of M. oleifera in
ISO-induced cardiotoxicity in rats. The effect at 500 mg/kg dose was
more pronounced. |
| Page(s): | 485-492 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJNPR Vol.1(4) [December 2010]
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