NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)]
 >
IJNPR Vol.1 [2010] >
IJNPR Vol.1(4) [December 2010] >


Title: Protective effect of aqueous extract of Moringa oleifera Lam. stem bark on serum lipids, marker enzymes and heart antioxidants parameters in isoproterenol-induced cardiotoxicity in Wistar rats
Authors: Gunjal, Mahendra A
Shah, Abhishek S
Wakade, Alok S
Juvekar, Archana R
Keywords: Moringa oleifera
Drumstick tree
Isoproterenol
Marker enzymes
Antioxidant enzymes
Cardioprotection
Hypolipidemic
Issue Date: Dec-2010
Publisher: NISCAIR-CSIR, India
IPC CodeInt. cl.8A61K 36/00, A61P 9/00, A61P 17/18
Abstract: Cardio protective potential of aqueous extract of Moringa oleifera Lam. (Family-Moringaceae) stem bark on serum lipids profiles, myocardial marker enzymes in serum and heart homogenate, antioxidant parameters in heart homogenate and histopathological findings in isoproterenol (ISO)-induced cardiotoxicity in rats was evaluated. Subcutaneous injection of ISO (85 mg/kg) to Wistar rats showed a significant (P<0.05) increase in the levels of thiobarbituric acid reactive substances along with a significant decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and reduced glutathione in the heart. It also significantly increased the level of cholesterol, triglycerides, VLDL and LDL with significant decrease in the level of HDL, increased the level of myocardial marker enzymes CK, LDH, ALT and AST in serum and concomitantly decreased in heart. Oral administration of aqueous extract of M. oleifera (250 and 500 mg/kg) to ISO-induced rats daily for a period of 21 days showed a significant improvement in lipid profile along with marker enzymes in serum and heart homogenate. It also decreased the levels of thiobarbituric acid reactive substances and improved antioxidant status by increasing the activities of antioxidant enzymes. Histopathological findings of the myocardial tissue showed the protective role of M. oleifera in ISO-induced cardiotoxicity in rats. The effect at 500 mg/kg dose was more pronounced.
Page(s): 485-492
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Source:IJNPR Vol.1(4) [December 2010]

Files in This Item:

File Description SizeFormat
IJNPR 1(4) 485-492.pdf340.24 kBAdobe PDFView/Open
 Current Page Visits: 861 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 623491 since 06-Feb-2009  Last updated on 13-Nov-2014Webmaster: nopr@niscair.res.in