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|Title:||Inhibition of UV induced adversaries by -glucogallin from Amla (Emblica officinalis Gaertn.) fruits|
Susmitha Anand, T S
|Series/Report no.:||Int. cl.8 - A61K 36/47, A61K 131/00, A61P 17/18, A61Q 17/00|
|Abstract:||Photoprotection efficacy of Amla (Emblica officinalis Gaertn.) fruit extract was investigated by various in vitro models. It was found that 1-O-Galloyl--D-glucose (-glucogallin) active in Amla extract has a significant role in photoprotection efficacy due to its inhibitory effect on Ultraviolet irradiation (UV) induced adversaries in cell cultures. -Glucogallin treatment at a concentration of 10 to 80 µg/ml in B16F1 mouse melanoma cells showed a dose dependent decrease of 15 to 55% in UV induced melanogenesis. -Glucogallin treatment at a concentration of 10 to 80 µg/ml, also showed a dose dependent decrease of 30 to 90% in UV induced cytotoxicity and a decrease of 42 to 82% in UV induced Reactive Oxygen Species (ROS) generation in Swiss 3T3 mouse fibroblast cells. It showed a very high Oxygen Radical Absorbance Capacity (ORAC) value of 4200 µmol Trolox equivalents/g. Our evaluations shown that -glucogallin from Amla extract has significant photoprotection efficacy.|
|ISSN:||0975-1033 (Online); 0379-5136 (Print)|
|Appears in Collections:||IJNPR Vol.1(4) [December 2010]|
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