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Title: Inhibition of UV induced adversaries by -glucogallin from Amla (Emblica officinalis Gaertn.) fruits
Authors: Majeed, Muhammed
Bhat, Beena
Susmitha Anand, T S
Keywords: Amla fruit;Antioxidant;Emblica officinalis;-Glucogallin;Photoprotection;Ultraviolet irradiation
Issue Date: Dec-2010
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl.8 - A61K 36/47, A61K 131/00, A61P 17/18, A61Q 17/00
Abstract: Photoprotection efficacy of Amla (Emblica officinalis Gaertn.) fruit extract was investigated by various in vitro models. It was found that 1-O-Galloyl--D-glucose (-glucogallin) active in Amla extract has a significant role in photoprotection efficacy due to its inhibitory effect on Ultraviolet irradiation (UV) induced adversaries in cell cultures. -Glucogallin treatment at a concentration of 10 to 80 µg/ml in B16F1 mouse melanoma cells showed a dose dependent decrease of 15 to 55% in UV induced melanogenesis. -Glucogallin treatment at a concentration of 10 to 80 µg/ml, also showed a dose dependent decrease of 30 to 90% in UV induced cytotoxicity and a decrease of 42 to 82% in UV induced Reactive Oxygen Species (ROS) generation in Swiss 3T3 mouse fibroblast cells. It showed a very high Oxygen Radical Absorbance Capacity (ORAC) value of 4200 µmol Trolox equivalents/g. Our evaluations shown that -glucogallin from Amla extract has significant photoprotection efficacy.
Page(s): 462-465
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJNPR Vol.1(4) [December 2010]

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