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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.1 [2010] >
IJNPR Vol.1(4) [December 2010] >
| Title: | Inhibition of UV induced adversaries by  -glucogallin from Amla (Emblica officinalis Gaertn.) fruits |
| Authors: | Majeed, Muhammed
Bhat, Beena
Susmitha Anand, T S |
| Keywords: | Amla fruit
Antioxidant
Emblica officinalis
-Glucogallin
Photoprotection
Ultraviolet irradiation |
| Issue Date: | Dec-2010 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl.8 - A61K 36/47, A61K 131/00, A61P 17/18, A61Q 17/00 |
| Abstract: | Photoprotection
efficacy of Amla (Emblica officinalis
Gaertn.) fruit extract was investigated by various in vitro models. It
was found that 1-O-Galloyl--D-glucose
(-glucogallin) active in Amla extract has a significant role in photoprotection efficacy due to its inhibitory effect
on Ultraviolet irradiation (UV) induced adversaries in cell cultures. -Glucogallin treatment at a concentration of 10 to 80 µg/ml in
B16F1 mouse melanoma cells showed a dose dependent decrease of 15 to 55% in UV
induced melanogenesis. -Glucogallin treatment at a concentration of 10 to 80 µg/ml, also
showed a dose dependent decrease of 30 to 90% in UV induced cytotoxicity and a
decrease of 42 to 82% in UV induced Reactive Oxygen Species (ROS) generation in
Swiss 3T3 mouse fibroblast cells. It showed a very high Oxygen Radical
Absorbance Capacity (ORAC) value of 4200 µmol Trolox equivalents/g. Our
evaluations shown that -glucogallin from Amla extract has
significant photoprotection efficacy. |
| Page(s): | 462-465 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJNPR Vol.1(4) [December 2010]
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