Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/10813
Title: Inhibition of UV induced adversaries by <img src='/image/spc_char/beta.gif' border=0>-glucogallin from Amla (<i>Emblica officinalis</i> Gaertn.) fruits
Authors: Majeed, Muhammed
Bhat, Beena
Susmitha Anand, T S
Keywords: Amla fruit
Antioxidant
<i style="">Emblica officinalis</i>
<img src='/image/spc_char/beta.gif' border=0>-Glucogallin
Photoprotection
Ultraviolet irradiation
Issue Date: Dec-2010
Publisher: NISCAIR-CSIR, India
Series/Report no.: <b>Int. cl.<sup>8</sup></b> - A61K 36/47, A61K 131/00, A61P 17/18, A61Q 17/00
Abstract: Photoprotection efficacy of Amla (<i style="">Emblica officinalis</i> Gaertn.) fruit extract was investigated by various <i>in vitro</i> models. It was found that 1-O-Galloyl-<img src='/image/spc_char/beta.gif' border=0>-D-glucose (<img src='/image/spc_char/beta.gif' border=0>-glucogallin) active in Amla extract has a significant role in photoprotection efficacy due to its inhibitory effect on Ultraviolet irradiation (UV) induced adversaries in cell cultures. <img src='/image/spc_char/beta.gif' border=0>-Glucogallin treatment at a concentration of 10 to 80 µg/ml in B16F1 mouse melanoma cells showed a dose dependent decrease of 15 to 55% in UV induced melanogenesis. <img src='/image/spc_char/beta.gif' border=0>-Glucogallin treatment at a concentration of 10 to 80 µg/ml, also showed a dose dependent decrease of 30 to 90% in UV induced cytotoxicity and a decrease of 42 to 82% in UV induced Reactive Oxygen Species (ROS) generation in Swiss 3T3 mouse fibroblast cells. It showed a very high Oxygen Radical Absorbance Capacity (ORAC) value of 4200 µmol Trolox equivalents/g. Our evaluations shown that <img src='/image/spc_char/beta.gif' border=0>-glucogallin from Amla extract has significant photoprotection efficacy.
Description: 462-465
URI: http://hdl.handle.net/123456789/10813
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJNPR Vol.1(4) [December 2010]

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