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Title: A novel spectrophotometric determination of atenolol using sodium nitroprusside
Authors: Bashir, Nadia
Shah, S W H
Bangesh, Masroor
Keywords: Atenolol;Deamination;Sodium nitroprusside;Spectrophotometry
Issue Date: Jan-2011
Publisher: NISCAIR-CSIR, India
Abstract: A simple, sensitive and new spectrophotometric method has been developed for determination of atenolol, a cardiovascular drug. Proposed method is based on deamination of atenolol in basic media, followed by addition of sodium nitroprusside to generate a coloured complex that absorbs at 495 nm. It gave following values: Beer’s law, 0.5-30 µg ml-1; molar absorptivity, 3.01×105; limit of detection, 0.0107 µg ml-1; and limit of quantification, 0.0358 µg ml-1. It was successfully employed for determination of active ingredient concentration in commercial formulations of atenolol.
Page(s): 51-54
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.70(01) [January 2011]

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