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Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.70 [2011] >
JSIR Vol.70(01) [January 2011] >
| Title: | A novel spectrophotometric determination of atenolol using sodium nitroprusside |
| Authors: | Bashir, Nadia
Shah, S W H
Bangesh, Masroor
Riazullah |
| Keywords: | Atenolol
Deamination
Sodium nitroprusside
Spectrophotometry |
| Issue Date: | Jan-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A simple, sensitive
and new spectrophotometric method has been developed for determination of
atenolol, a cardiovascular drug. Proposed method is based on deamination of
atenolol in basic media, followed by addition of sodium nitroprusside to
generate a coloured complex that absorbs at 495 nm. It gave following values:
Beer’s law, 0.5-30 µg ml-1; molar absorptivity, 3.01×105 l.mol-1.cm-1;
limit of detection, 0.0107 µg ml-1; and limit of quantification,
0.0358 µg ml-1. It was successfully employed for determination of
active ingredient concentration in commercial formulations of atenolol. |
| Page(s): | 51-54 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.70(01) [January 2011]
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