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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(01) [January 2011] >
| Title: | Effect of topical phenytoin on burn wound healing in rats |
| Authors: | Meena, K
Mohan, A V
Sharath, B
Somayaji, S N
Bairy, K L |
| Keywords: | Epithelialization
Phenytoin
Silver sulphadiazine
Wound contraction |
| Issue Date: | Jan-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | To evaluate the effect of phenytoin on burn
wounds and to compare the effect of the combination of topical phenytoin
preparation in dexamethasone treated burn wounds in rats, partial thickness thermal
burn wounds were inflicted upon five groups of six rats each. Group I was
assigned as control, Group II received the standard silver sulphadiazine, Group
III was given topical phenytoin and Group IV received injection dexamethasone,
Group V received the combination of the phenytoin and the dexamethasone. The
parameters observed were epithelialization period, percentage of wound
contraction and histopathological analysis as indicative of the process of
healing. Phenytoin group showed significant improvement in burn wound
contraction in comparison to standard silver sulphadiazine group, the
combination group of topical phenytoin and dexamethasone also showed
significant contraction compared to dexamethasone group. The period of
epithelialization also decreased significantly in groups II, III and V. In
conclusion, phenytoin promotes burn wound healing as evidenced by decrease in
period of epithelialization and faster wound contraction. |
| Page(s): | 56-59 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(01) [January 2011]
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