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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(01) [January 2011] >
| Title: | Effect of Bis [benzyl N'-(indol-3-ylmethylene)-hydrazinecarbodithioato]-zinc(II) derivatives on wound healing in Sprague Dawley rats |
| Authors: | Mughrabi, Fathi Farag
Hashim, Harita
Ameen, Mahmood
Khaledi, Hamid
Ali, Hapipah Mohd.
Ismail, Salmah |
| Keywords: | BHCZ derivatives
Histology
Intrasite gel
Wound healing |
| Issue Date: | Jan-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Effects of topical application of Bis[benzyl N'-(indol-3-ylmethylene)-hydrazinecarbodithioato]-zinc(II) (BHCZ)
on wound healing and histology of healed wound were assessed. Sprague Dawley
rats were experimentally induced wound in the posterior neck area. Tween 20
(0.2 ml of 10%) was applied to rats in Group 1 (negative control). Intrasite
gel (0.2 ml) was applied topically to rats in Group 2 as reference. BHCZ at the
concentrations 0.2 ml of 25, 50 and 100 mg/ml were applied to Group 3, 4 and 5,
respectively. Wound dressed with BHCZ significantly healed earlier than those
treated with 10% Tween 20. Also wound dressed with 100 mg/ml BHCZ accelerated
the rate of wound healing compared to those dressed with intrasite gel and, 25
mg/ml and 50 mg/ml BHCZ. Histological analysis of healed wound with BHCZ showed
comparatively less scar width at wound enclosure and the healed wound contained
less macrophages and large amount of collagen with angiogenesis compared to
wounds dressed with 10% Tween 20. Results of this study showed that wounds
dressed with 100 mg/ml of BHCZ significantly enhanced acceleration of the rate
of wound healing enclosure, and histology of healed wounds showed comparatively
less macrophages and more collagen with angiogenesis. |
| Page(s): | 50-55 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(01) [January 2011]
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