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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(01) [January 2011] >
| Title: | Hepato-protective potential of carotenoid meso-zeaxanthin against paracetamol, CCl4 and ethanol induced toxicity |
| Authors: | Firdous, Alikunjhi P
Sindhu, Edakkadath R
Kuttan, Ramadasan |
| Keywords: | Antioxidant
Carotenoids
CCl4
Ethanol
Free radicals
Paracetamol |
| Issue Date: | Jan-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Hepato-protective potential of carotenoid meso-zeaxanthin [(3R, 3’S)- ,
-carotene-3, 3′-diol] was studied using
in vivo rat models. Paracetamol (3 g/kg
body wt, orally), 20% ethanol (7.5 g/kg body wt, orally) and CCl4 (2.5ml
/kg, ip) were used as hepato toxins. Levels of marker enzymes of hepatic injury
such as serum glutamate oxaloacetate transaminase, serum glutamate pyruvate
transaminase and alkaline phosphatase, and serum bilirubin, which were
drastically elevated by these hepato toxins were significantly decreased by meso-zeaxanthin pretreatment in a dose-dependent
manner. Oxidative stress markers, tissue lipid peroxidation, conjugated dienes
and tissue hydroperoxides, were high in the paracetamol treated control group
animals, which were lowered by meso-zeaxanthin
administration. Level of glutathione and antioxidant enzymes, superoxide
dismutase, catalase and glutathione peroxidase, in liver tissue was increased by
meso-zeaxanthin pretreatment compared
to control group during alcohol and CCl4 induced hepatotoxicity. Hydroxyproline,
an indicator of fibrosis in liver tissue, decreased remarkably by meso-zeaxanthin administration despite
its notable elevation in ethanol treated rats. Histopathological analysis of
liver tissue showed the hepatoprotective potential of meso-zeaxanthin. |
| Page(s): | 44-49 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(01) [January 2011]
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