Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/10763
Title: Antioxidant potential of n-butanol fraction from extract<i style=""> </i>of<i style=""> Jasminum mesnyi</i> Hance leaves
Authors: Borar, Sakshi
Punia, Priyanka
Kalia, A N
Keywords: Antihyperglycemic
Antioxidant
<i style="">Jasminum mesnyi</i>
Secoiridoids
Issue Date: Jan-2011
Publisher: NISCAIR-CSIR, India
Abstract: Methanolic extract of <i style="">Jasminum mesnyi </i>Hance leaves having antidiabetic activity was subjected to fractionation to obtain antioxidant and antihyperglycemic rich fraction. Different concentrations of ethyl acetate and n-butanol fractions were subjected to antioxidant assay by DPPH method, nitric oxide scavenging activity and reducing power assay. The fractions showed dose dependent free radical scavenging property in all the models. IC<sub>50</sub> values for ethyl acetate and n-butanol fractions were 153.45±6.65 and 6.22±0.25 <img src='/image/spc_char/micro.gif' border=0> g/ml, respectively, as compared to L-ascorbic acid and rutin (as standards; IC<sub>50 </sub>values 6.54±0.24 and 5.43±0.21 <img src='/image/spc_char/micro.gif' border=0> g/ml, respectively) in DPPH model. In nitric oxide scavenging activity, IC<sub>50</sub> values were 141.54±9.95 <img src='/image/spc_char/micro.gif' border=0> g/ml, 35.12±1.58 <img src='/image/spc_char/micro.gif' border=0> g/ml, 21.06±0.95 <img src='/image/spc_char/micro.gif' border=0> g/ml and 29.93±0.32 <img src='/image/spc_char/micro.gif' border=0> g/ml for ethyl acetate, n-butanol fractions, L-ascorbic acid and rutin, respectively. n-Butanol fraction showed a good reducing potential and better free radical scavenging activity as compared to ethyl acetate fraction. Potent antioxidant n-butanol fraction showed better oral glucose tolerance test (antihyperglycemic) at par with metformin (standard drug). n-Butanol fraction contained secoiridoid glycosides which might be responsible for both antioxidant and antihyperglycemic activity.
Description: 39-43
URI: http://hdl.handle.net/123456789/10763
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(01) [January 2011]

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