|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(01) [January 2011] >
| Title: | Antioxidant potential of n-butanol fraction from extract of Jasminum mesnyi Hance leaves |
| Authors: | Borar, Sakshi
Punia, Priyanka
Kalia, A N |
| Keywords: | Antihyperglycemic
Antioxidant
Jasminum mesnyi
Secoiridoids |
| Issue Date: | Jan-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Methanolic extract of Jasminum mesnyi Hance leaves having antidiabetic activity was
subjected to fractionation to obtain antioxidant and antihyperglycemic rich
fraction. Different concentrations of ethyl acetate and n-butanol fractions
were subjected to antioxidant assay by DPPH method, nitric oxide scavenging
activity and reducing power assay. The fractions showed dose dependent free
radical scavenging property in all the models. IC50 values for ethyl
acetate and n-butanol fractions were 153.45±6.65 and 6.22±0.25  g/ml, respectively, as compared to L-ascorbic acid and rutin (as
standards; IC50 values 6.54±0.24 and 5.43±0.21 g/ml, respectively) in DPPH model. In nitric oxide
scavenging activity, IC50 values were 141.54±9.95 g/ml, 35.12±1.58 g/ml, 21.06±0.95 g/ml and 29.93±0.32
g/ml for ethyl acetate, n-butanol fractions,
L-ascorbic acid and rutin, respectively. n-Butanol fraction showed a good
reducing potential and better free radical scavenging activity as compared to
ethyl acetate fraction. Potent antioxidant n-butanol fraction showed better
oral glucose tolerance test (antihyperglycemic) at par with metformin (standard
drug). n-Butanol fraction contained secoiridoid glycosides which might be
responsible for both antioxidant and antihyperglycemic activity. |
| Page(s): | 39-43 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(01) [January 2011]
|
|
