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Title: Antidiabetic properties of <i>Hibiscus rosa sinensis </i>L. leaf extract fractions on non-obese diabetic (NOD) mouse
Authors: Moqbel, Fahmi S
Naik, Prakash R
Najma, Habeeb M
Selvaraj, S
Keywords: Cholesterol
Glycosylated haemoglobin
<i>H. rosa sinensi</i>
Issue Date: Jan-2011
Publisher: NISCAIR-CSIR, India
Abstract: On fractionation the ethanolic extract of <i>H. rosa sinensis</i> leaves, 5 fractions were obtained. Of these, fraction-3 (F<sub>3</sub>) and fraction-5 (F<sub>5</sub>) were chosen for detailed investigation on non obese diabetic (NOD) mouse to study anti-diabetic properties because they were more active than others. Serum glucose, glycosylated hemoglobin, triglyceride, cholesterol, blood urea, insulin, LDL, VLDL, and HDL were estimated. Both fractions F<sub>3</sub> and F<sub>5</sub> on oral feeding (100 and 200 mg/kg body weight) demonstrated insulinotropic nature and protective effect in NOD mice. These fractions may contain potential oral hypoglycemic agent.
Description: 24-29
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(01) [January 2011]

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