Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/10758
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dc.contributor.authorHusain, Aliabbas A-
dc.contributor.authorKashyap, Rajpal S-
dc.contributor.authorKalorey, Devanand R-
dc.contributor.authorWarke, Shubangi R-
dc.contributor.authorPurohit, Hemant J-
dc.contributor.authorTaori, Girdhar M-
dc.contributor.authorDaginawala, Hatim F-
dc.date.accessioned2010-12-27T04:30:41Z-
dc.date.available2010-12-27T04:30:41Z-
dc.date.issued2011-01-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/10758-
dc.description7-10en_US
dc.description.abstractBCG is the only vaccine presently available against tuberculosis but it is estimated to prevent only 5% of the all potentially vaccine-preventable deaths due to Tuberculosis. Keeping these in view the present study has been undertaken to evaluate the efficacy of BCG and the effect of repeat dose of BCG on antimycobacterial humoral response in mouse model. To improve BCG immunogenicity, specific anti-mycobacterial immune responses (anti-BCG titre and total IgG level) were evaluated in mouse model using boost immunization protocols with the BCG vaccine. Mice induced with a repeat dose of BCG showed an increased anti mycobacterial humoral response, which gradually declined few weeks after single dose of BCG administration. The results suggest improved efficacy of BCG vaccine by giving repeat dose of BCG that can enhance the level of immunoprotection against tuberculosis as opposed to a single BCG dose.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.49(01) [January 2011]en_US
dc.subjectAnti-BCG titeren_US
dc.subjectBCGen_US
dc.subjectTuberculosisen_US
dc.titleEffect of repeat dose of BCG vaccination on humoral response in mice modelen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.49(01) [January 2011]

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