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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(01) [January 2011] >
| Title: | Effect of repeat dose of BCG vaccination on humoral response in mice model |
| Authors: | Husain, Aliabbas A
Kashyap, Rajpal S
Kalorey, Devanand R
Warke, Shubangi R
Purohit, Hemant J
Taori, Girdhar M
Daginawala, Hatim F |
| Keywords: | Anti-BCG titer
BCG
Tuberculosis |
| Issue Date: | Jan-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | BCG is the only vaccine presently available against
tuberculosis but it is estimated to prevent only 5% of the all potentially
vaccine-preventable deaths due to Tuberculosis. Keeping these in view the
present study has been undertaken to evaluate the efficacy of BCG and the
effect of repeat dose of BCG on antimycobacterial humoral response in mouse
model. To improve BCG immunogenicity, specific anti-mycobacterial immune
responses (anti-BCG titre and total IgG level) were evaluated in mouse model
using boost immunization protocols with the BCG vaccine. Mice
induced with a repeat dose of BCG showed an increased anti mycobacterial
humoral response, which gradually declined few weeks after single dose of BCG
administration. The results suggest improved efficacy of BCG vaccine by giving
repeat dose of BCG that can enhance the level of immunoprotection against
tuberculosis as opposed to a single BCG dose. |
| Page(s): | 7-10 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(01) [January 2011]
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