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dc.contributor.authorMariappan, G-
dc.contributor.authorSaha, B P-
dc.contributor.authorSutharson, L-
dc.contributor.authorHaldar, A-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstract3-Methyl-4-substituted benzylidene-pyrazol-5-ones 1-10 are synthesized by the condensation of 3-methyl-pyrazol-5-one with substituted aliphatic and aromatic aldehydes. Their structures have been elucidated from UV-Vis, IR, 1H NMR and mass spectral data. Among the synthesized derivatives 5, 6, 7 and 10 are found to have a potent anti-inflammatory response whereas compounds 1, 4, 5, 8 and 10 have an effective analgesic response. There is no remarkable difference in bioactivity of pyrazolones derived from aliphatic and aromatic aldehydes. All the experimental data are statistically significant at p<0.05.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.49B(12) December 2010]en_US
dc.subjectprotein kinase C inhibitoren_US
dc.titleSynthesis and bioactivity evaluation of pyrazolone derivativesen_US
Appears in Collections:IJC-B Vol.49B(12) December 2010]

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