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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(12) December 2010] >
| Title: | Synthesis and bioactivity evaluation of pyrazolone derivatives |
| Authors: | Mariappan, G
Saha, B P
Sutharson, L
Haldar, A |
| Keywords: | Pyrazolone
analgesic
anti-inflammatory
protein kinase C inhibitor |
| Issue Date: | Dec-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 3-Methyl-4-substituted
benzylidene-pyrazol-5-ones 1-10 are synthesized by the condensation of
3-methyl-pyrazol-5-one with substituted aliphatic and aromatic aldehydes. Their
structures have been elucidated from UV-Vis, IR, 1H NMR and mass
spectral data. Among the synthesized derivatives 5, 6, 7 and 10 are found
to have a potent anti-inflammatory response whereas compounds 1, 4, 5, 8 and 10 have an effective analgesic response. There is no remarkable difference in bioactivity of pyrazolones derived
from aliphatic and aromatic aldehydes. All the experimental data are
statistically significant at p<0.05. |
| Page(s): | 1671-1674 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(12) December 2010]
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