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IJC-B Vol.49B(12) December 2010] >


Title: Synthesis and bioactivity evaluation of pyrazolone derivatives
Authors: Mariappan, G
Saha, B P
Sutharson, L
Haldar, A
Keywords: Pyrazolone
analgesic
anti-inflammatory
protein kinase C inhibitor
Issue Date: Dec-2010
Publisher: NISCAIR-CSIR, India
Abstract: 3-Methyl-4-substituted benzylidene-pyrazol-5-ones 1-10 are synthesized by the condensation of 3-methyl-pyrazol-5-one with substituted aliphatic and aromatic aldehydes. Their structures have been elucidated from UV-Vis, IR, 1H NMR and mass spectral data. Among the synthesized derivatives 5, 6, 7 and 10 are found to have a potent anti-inflammatory response whereas compounds 1, 4, 5, 8 and 10 have an effective analgesic response. There is no remarkable difference in bioactivity of pyrazolones derived from aliphatic and aromatic aldehydes. All the experimental data are statistically significant at p<0.05.
Page(s): 1671-1674
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(12) December 2010]

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