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IJC-B Vol.49B(12) December 2010] >


Title: Synthesis and biological screening of novel derivatives of 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles
Authors: Manikrao, Anil M
Fursule, Ravindra A
Rajesh, K S
Kunjwani, Harish K
Sabale, Prafulla M
Keywords: 1-Formylthiosemicarbazide
1,2,4-triazole
analgesic
anti-inflammatory
anxiolytic
Issue Date: Dec-2010
Publisher: NISCAIR-CSIR, India
Abstract: 3-Mercapto-(4H)-1,2,4-triazole has been synthesized from 1-formylthiosemicarbazide. Different N-substituted β-chloropropionamides have been prepared by reacting substituted amines with β-chloropropionylchloride. Different N-substituted β-chloropropionamides have been condensed with 3-mercapto-(4H)-1,2,4-triazole in basic medium to obtain various 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles. The structure of the synthesized compounds are confirmed by IR, 1H NMR spectra and elemental analysis. All the compounds have been screened for their analgesic, anti-inflammatory and anxiolytic activity.
Page(s): 1642-1647
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(12) December 2010]

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