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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(12) [December 2010] >
| Title: | Oily fraction of Semecarpus anacardium Linn nuts involves protein kinase C activation for its pro-inflammatory response |
| Authors: | Tripathi, Yamini B
Pandey, Nidhi
Tripathi, Deepshikha
Tripathi, Pratibha |
| Issue Date: | Dec-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The oily fraction (non polar fraction-NPF) of S. anacardium (SA) significantly
increased the expression of protein kinase C-δ (PKC-δ) in macrophages in
concentration dependent manner, which was similar to phorbol myristate acetate (PMA)
response. Further, H-7 (1-(5-isoquinolinesulphonyl)-2-methylpiperazine),
an inhibitor of PKC significantly inhibited this NPF mediated response in a
concentration dependent manner. In the post treatment kinetics, H-7 showed this
inhibition only up to 6 min post NPF/PMA addition, but in similar condition,
quercetin, a flavone with reported antioxidant property, showed this inhibition
only up to 2 min. The results clearly suggest that oily fraction of SA nuts
enhances the expression of PKC protein, which may be responsible for its
reported pro-inflammatory property. |
| Page(s): | 1204-1209 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(12) [December 2010]
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