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Title: Oily fraction of Semecarpus anacardium Linn nuts involves protein kinase C activation for its pro-inflammatory response
Authors: Tripathi, Yamini B
Pandey, Nidhi
Tripathi, Deepshikha
Tripathi, Pratibha
Issue Date: Dec-2010
Publisher: NISCAIR-CSIR, India
Abstract: The oily fraction (non polar fraction-NPF) of S. anacardium (SA) significantly increased the expression of protein kinase C-δ (PKC-δ) in macrophages in concentration dependent manner, which was similar to phorbol myristate acetate (PMA) response. Further, H-7 (1-(5-isoquinolinesulphonyl)-2-methylpiperazine), an inhibitor of PKC significantly inhibited this NPF mediated response in a concentration dependent manner. In the post treatment kinetics, H-7 showed this inhibition only up to 6 min post NPF/PMA addition, but in similar condition, quercetin, a flavone with reported antioxidant property, showed this inhibition only up to 2 min. The results clearly suggest that oily fraction of SA nuts enhances the expression of PKC protein, which may be responsible for its reported pro-inflammatory property.
Page(s): 1204-1209
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.48(12) [December 2010]

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