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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(12) [December 2010] >
| Title: | Vasoprotection by melatonin and quercetin in rats treated with cisplatin |
| Authors: | Atalık, K E
Keleş, B
Uyar, Y
Dündar, M A
Öz, M
Esen, H H |
| Keywords: | Aorta
Cisplatin
Melatonin
Quercetin
Vasoprotection |
| Issue Date: | Dec-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Cisplatin-based chemotherapy has a variety
of vascular side effects. The aim of the present study was to evaluate the
beneficial effect of melatonin and cisplatin on the alterations in vascular
reactivity and structure of cisplatin-treated rats. Phenylephrine (PHE) and
KCl-caused concentration-dependent contractions of rat aorta. Pretreatment with
cisplatin increased the sensitivity but not the max response to PHE and KCl. In
rats treated with melatonin or quercetin before cisplatin, the EC50
values, but not the maximal response to both agents were significantly higher
than cisplatin-treated group. Compared to the control group,
cisplatin-treatment significantly reduced the luminal area of the aorta. In
melatonin and quercetin-treated aortas the luminal area values were significantly
higher than cisplatin-treated group. The results demonstrate for the first time
that melatonin and quercetin treatment may protect the aorta in cisplatin-based
chemotherapy. |
| Page(s): | 1188-1193 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(12) [December 2010]
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