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IJC-B Vol.45B(04) [April 2006] >


Title: Condensed bridgehead nitrogen heterocyclic systems: Microwave assisted synthesis and bioactivity of s-triazolo[3,4- ][1,3,4]thiadiazoles, s-triazolo[3,4- ][1,3,4]thiadiazines and s-triazolo [3' ,4' :2,3]-thiadiazino[5,6- ]quinoxaline
Authors: Shiradkar, Mahendra
Kale, Rajesh
Keywords: Bridgehead nitrogen heterocycle
microwave synthesis
bioactivity
thiadiazole
quinoxaline
Issue Date: Apr-2006
Publisher: NISCAIR-CSIR, India
IPC CodeInt.Cl.7 C 0 7 D
Abstract: N-[3-(4-Amino-5-mercapto-4 -[1,2,3]triazol-3-yl)-4,5,6,7-tetrahydrobenzo[ ] thiophen-2-yl]acetamide 1 on condensation with chloroac etic acid, -haloketone and benzoin furnishes [1,2,4]triazolo[3,4- ][1,3,4]thiadiazine derivatives 2,3 and 4 respectively, while condens ation with 2,3-dichloroquinoxaline, carbon disulphide, aromatic c arboxylic ac id and aromatic carboxaldehydes yield the cyclic products, [1,2,4] triazolo[3,4- ][1,3,4]thiadiazole derivatives 5, 6, 7,8 respectively. The compounds have been characterized on the basis of elemental analysis and spectral data. The antibacterial, antifungal and antitubercular activities of the compounds have also been evaluated.
Page(s): 1009-1013
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(04) [April 2006]

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