Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/10564
Title: Synthesis of substituted 3-cyano-2-pyridones: Part IV Influence of 3-alkyl-2,4-pentanedione and N-alkyl cyanoacetamide structure on the enzyme catalyzed synthesis of substituted 3-cyano-2-pyridones
Authors: Mijin, Dušan ÆZ
Mili, Branislav D
Miši, Milica M
Keywords: Pyridone
lipase
diketone
cyanoacetamide
Issue Date: Apr-2006
Publisher: NISCAIR-CSIR, India
Series/Report no.: Int.Cl.7 C 07 D
Abstract: Lipase from Candida rugosa has been used to study the influence of 3-alkyl-2,4-pentanedione and N-alkyl cyanoacetamidestructure on the enzyme catalyzed reaction of pyridone ring formation in water at 40oC. Starting with 1,3-diketones andcyanoacetamides and for comparison, the expected corresponding substituted 3-cyano-2-pyridones have been synthesized bychemical methods. Bulkier substituents lower the initial reaction rate of the enzyme catalyzed reactions and consequently theyield of the corresponding pyridones. N-alkyl cyanoacetamides are more reactive in comparison to the corresponding 3-alkyl-2,4-pentanediones with respect to the obtained yields of the corresponding substituted 3-cyano-2-pyridones..
Description: 993-1003
URI: http://hdl.handle.net/123456789/10564
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(04) [April 2006]

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