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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(04) [April 2006] >
| Title: | Synthesis of substituted 3-cyano-2-pyridones: Part IV Influence of 3-alkyl-2,4-pentanedione and N-alkyl cyanoacetamide structure on the enzyme catalyzed synthesis of substituted 3-cyano-2-pyridones |
| Authors: | Mijin, Dušan ÆZ
Mili, Branislav D
Miši, Milica M |
| Keywords: | Pyridone
lipase
diketone
cyanoacetamide |
| Issue Date: | Apr-2006 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int.Cl.7 C 07 D |
| Abstract: | Lipase from Candida rugosa has been used to study the influence of 3-alkyl-2,4-pentanedione and N-alkyl cyanoacetamidestructure on the enzyme catalyzed reaction of pyridone ring formation in water at 40oC. Starting with 1,3-diketones andcyanoacetamides and for comparison, the expected corresponding substituted 3-cyano-2-pyridones have been synthesized bychemical methods. Bulkier substituents lower the initial reaction rate of the enzyme catalyzed reactions and consequently theyield of the corresponding pyridones. N-alkyl cyanoacetamides are more reactive in comparison to the corresponding 3-alkyl-2,4-pentanediones with respect to the obtained yields of the corresponding substituted 3-cyano-2-pyridones.. |
| Page(s): | 993-1003 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(04) [April 2006]
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