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Title: A facile one-pot synthetic route to substituted fused tetrahydropyrimidines. Part 41: Synthesis of 1-(aralkyl/aryl)-3- (alkyl/aralkyl/aryl)-5-oxo-1,2,3,4,5,6,7,8- octahydroquinazolines and 1-(aralkyl/aryl)-3- (alkyl/aralkyl/aryl)-7,7-dimethyl-5-oxo- 1,2,3,4,5,6,7,8-octahydroquinazolines
Authors: Chanda, Kaushik
Dutta, Milan C
Vishwakarma, Jai N
Keywords: Octahydroquinazolines;cyclocondensation;cyclic enaminones;formaldehyde;primary amines
Issue Date: Apr-2006
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07 D
Abstract: A facile one pot pathway has been developed for the synthesis of novel 1-(aralkyl/aryl)-3-(alkyl/aralkyl/a yl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazolines 2a-e and 1-(aralkyl/aryl)-3-( alkyl/ ar a lkyl/a ryl) -7, 7-dime thyl-5-oxo-1, 2, 3,4,5,6, ,8-octahydroquinazolines2f-k  by the cyc locondensation of cyclic enaminones 1a-d with formaldehyde and primary amines in refluxing methanol in good yields
Page(s): 1076-1079
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(04) [April 2006]

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