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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(04) [April 2006] >
| Title: | Synthesis and biological evaluation of new pyrimidine derivatives |
| Authors: | Fathalla, O A
Radwan, H H
Awad, S M
Mohamed, M S |
| Keywords: | Arylazo-pyrimidine derivatives
antibacterial activity
anticancer activity |
| Issue Date: | Apr-2006 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int.Cl.7 A 61 K |
| Abstract: | 4-Oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine (2-thiouracil)
1 is reacted with a series of diazotized aromatic amines to give compounds 2a-f.
On the other hand compound 1 is s-methylated by methyl iodide giving 4-oxo-2-methylthioxo
1,2,3,4-tetrahydropyrimidine 3, which inturn is reacted with a series of
diazotized aromatic amines giving arylazo derivatives of the type 4a-e. In
another reaction compound 1 is hydrolysed by monochloroacetic acid in
hydrochloric acid into 2,4-dioxo,1,2,3,4tetrahydropyrimidine (uracil) 5 which
is reacted with a series of diazotized aromatic giving aryl azo compounds of
the type 6a-f. The products showed some cytotoxic activity in addition to
antibacterial activity (compounds 2a, 4c, 4d and 6d) and antimicrobial activity
(compounds 2a, 4a-e and 6a-f). |
| Page(s): | 980-985 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(04) [April 2006]
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