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Title: Synthesis and biological evaluation of new pyrimidine derivatives
Authors: Fathalla, O A
Radwan, H H
Awad, S M
Mohamed, M S
Keywords: Arylazo-pyrimidine derivatives;antibacterial activity;anticancer activity
Issue Date: Apr-2006
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 A 61 K
Abstract: 4-Oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine (2-thiouracil) 1 is reacted with a series of diazotized aromatic amines to give compounds 2a-f. On the other hand compound 1 is s-methylated by methyl iodide giving 4-oxo-2-methylthioxo 1,2,3,4¬≠-tetrahydropyrimidine 3, which inturn is reacted with a series of diazotized aromatic amines giving arylazo derivatives of the type 4a-e. In another reaction compound 1 is hydrolysed by monochloroacetic acid in hydrochloric acid into 2,4-dioxo,1,2,3,4¬≠tetrahydropyrimidine (uracil) 5 which is reacted with a series of diazotized aromatic giving aryl azo compounds of the type 6a-f. The products showed some cytotoxic activity in addition to antibacterial activity (compounds 2a, 4c, 4d and 6d) and antimicrobial activity (compounds 2a, 4a-e and 6a-f).
Page(s): 980-985
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(04) [April 2006]

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