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Title: Synthesis and biological activities ofprenylated tyrosine derivatives, themetabolites of Pithomyces ellis
Authors: Venkateswarlu, Somepalli
Panchagnula, Gopala K
Subbaraju, Gottumukkala V
Keywords: Prenylated tyrosine;metabolites;Pithomyces ellis;4- hydroxyphenylacetic acid;antioxidant activity;antibacterial activity
Issue Date: Apr-2006
Publisher: NISCAIR-CSIR, India
IPC Code: Int.Cl.7 C 07 C
Abstract: 2-[4-(2E )-3-Methylbut-2-enyloxy)phenyl]ethan-1-ol 3 and 3-[4- (2E )-3-methylbut-2-enyloxy) phenyl]-2-(acetylamino)propanoic Acid 8 have been synthesized from 4-hydroxyphenylacetic acid 1 ,L-tyrosine 4 ,respectively, with an overall yield of 55% and 37%.The spectral data of synthetic 3 and 8 are in good agreement with those of natural 3 and 8, respectively These synthetic 3 and 8 show significant brine shrimp lethality, but weak antioxidant and antibacterial ac tivities.
Page(s): 1063-1066
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(04) [April 2006]

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