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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(04) [April 2006] >
| Title: | Studies on spiroheterocycles part-I: Installation of biologically active heterocyclic nuclei into spiro compounds derived from cyclohexanone and diphenyl thiobarbituric acid |
| Authors: | Behera, R K
Behera, A K
Pradhan, Rosy
Patra, M |
| Keywords: | Spiroheterocycles
diphenyl thiobarbituric acid
pyrazole
isooxazole
pyrimidine
antimicrobial activities |
| Issue Date: | Apr-2006 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int.Cl7 C07 D |
| Abstract: | Diarylidene ketones 1a-c, prepared by
the condensation of acetone with different appropriate aldehydes, on Michael
addition with 1,3-diphenyl-thiobarbituric acids afford the desired spiro
compounds 2a-c. The diarylidene derivatives 3a-l undergo cyclisation with
hydrazine, phenyl hydrazine, hydroxylamine, urea and guanidine carbonate to
furnish pyrazole 4a-l, phenyl pyrazole 5a-l, isoxazole 6a-l, pyrimidine 7a-l, and
aminopyrimidine 8a-l compounds, respectively. The structures of all the
compounds have been confirmed on the basis of their analytical, IR, NMR and
Mass spectral data. The antimicrobial activities |
| Page(s): | 933-942 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(04) [April 2006]
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