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Title: Studies on spiroheterocycles part-I: Installation of biologically active heterocyclic nuclei into spiro compounds derived from cyclohexanone and diphenyl thiobarbituric acid
Authors: Behera, R K
Behera, A K
Pradhan, Rosy
Patra, M
Keywords: Spiroheterocycles;diphenyl thiobarbituric acid;pyrazole;isooxazole;pyrimidine;antimicrobial activities
Issue Date: Apr-2006
Publisher: NISCAIR-CSIR, India
IPC Code:  Int.Cl7 C07 D
Abstract: Diarylidene ketones 1a-c, prepared by the condensation of acetone with different appropriate aldehydes, on Michael addition with 1,3-diphenyl-thiobarbituric acids afford the desired spiro compounds 2a-c. The diarylidene derivatives 3a-l undergo cyclisation with hydrazine, phenyl hydrazine, hydroxylamine, urea and guanidine carbonate to furnish pyrazole 4a-l, phenyl pyrazole 5a-l, isoxazole 6a-l, pyrimidine 7a-l, and aminopyrimidine 8a-l compounds, respectively. The structures of all the compounds have been confirmed on the basis of their analytical, IR, NMR and Mass spectral data. The antimicrobial activities
Page(s): 933-942
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(04) [April 2006]

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