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Title: Synthesis of Gossypin derivatives as potential anticancer and anti-inflammatory agents
Authors: Kotra, Vijay
Ganapaty, S
Adapa, Srinivas R
Keywords: Gossypin analogues;anticancer activity;anti-inflammatory activity
Issue Date: Nov-2010
Publisher: NISCAIR-CSIR, India
Abstract: Gossypin-a potential lead from nature is isolated and a series of its derivatives (SGGOS 1-9) were synthesized and characterized by IR, 1H NMR, mass spectral and elemental analyses. The in vitro cytotoxic activity on HT29 and HeLa cell lines, and in vivo anti-inflammatory activities of the compounds were evaluated. The synthesized variants have shown good anticancer and anti-inflammatory activities compared to gossypin.
Page(s): 1542-1546
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(11) [November 2010]

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