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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(11) [November 2010] >
| Title: | 2-Amino-5-sulphanyl-1,3,4-thiadiazole derivatives as anticonvulsant agents: Synthesis and evaluation [RETRACTED ARTICLE] |
| Authors: | Pattanayak, Priyabrata
Sharma, Rajesh |
| Keywords: | Maximal electroshock
PTZ animal model
thiadiazoles |
| Issue Date: | Nov-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of
2-amino-5-sulphanyl-1,3,4-thiadiazole derivatives bearing different
substituents have been synthesized and screened in order to evaluate for their
central nervous system activity. Anticonvulsant activity of the title compounds
has been evaluated by varying the substituents in the thiadiazole moiety. The
newly synthesized intermediates and compounds have been characterized by
spectral analysis. Two of the tested compounds 3a and 3b have been
found to exhibit excellent anticonvulsant activity in comparison to the
reference drugs in both the pharmacological models. |
| Page(s): | 1531-1534 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(11) [November 2010]
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