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IJC-B Vol.49B [2010] >
IJC-B Vol.49B(11) [November 2010] >


Title: Synthesis of N1-(3-chloro-4-flourophenyl)-N4-substituted semicarbazones as novel anticonvulsant agents
Authors: Amir, Mohd
Ahsan, Mohd J
Ali, Israr
Keywords: Semicarbazones
MES
neurotoxicity
CNS depressant activity
Issue Date: Nov-2010
Publisher: NISCAIR-CSIR, India
Abstract: Several 3-chloro-4-flourophenyl substituted semicarbazones have been synthesized in three steps involving aryl urea and aryl semicarbazide formation. The structures have been confirmed by spectral and elemental analyses. Some selected compounds have been evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) test. The compounds have also been screened for their neurotoxicity and CNS depressant activity. Compound 3i, N1-(3-chloro-4-fluorophenyl)-N4-(4-N,N-dimethylamino-benzaldehyde) semicarbazone is found most active of the series without neurotoxicity and less CNS depressant effect as compared to standard drug.
Page(s): 1509-1514
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(11) [November 2010]

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