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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(11) [November 2010] >
| Title: | Synthesis of N1-(3-chloro-4-flourophenyl)-N4-substituted semicarbazones as novel anticonvulsant agents |
| Authors: | Amir, Mohd
Ahsan, Mohd J
Ali, Israr |
| Keywords: | Semicarbazones
MES
neurotoxicity
CNS depressant activity |
| Issue Date: | Nov-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Several 3-chloro-4-flourophenyl substituted
semicarbazones have been synthesized in three steps involving aryl urea and
aryl semicarbazide formation. The structures have been confirmed by spectral
and elemental analyses. Some selected compounds have been evaluated for
anticonvulsant activity by using maximal electroshock seizure (MES) test. The
compounds have also been screened for their neurotoxicity and CNS depressant activity.
Compound 3i, N1-(3-chloro-4-fluorophenyl)-N4-(4-N,N-dimethylamino-benzaldehyde)
semicarbazone is found most active of the series
without neurotoxicity and less CNS depressant effect as compared to standard
drug. |
| Page(s): | 1509-1514 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(11) [November 2010]
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