|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(11) [November 2010] >
| Title: | Design, synthesis and in vivo hypoglycemic activity of tetrazole-bearing N-glycosides as SGLT2 inhibitors |
| Authors: | Gao, Y L
Zhao, G L
Liu, W
Shao, H
Wang, Y L
Xu, W R
Tang, L D
Wang, J W |
| Keywords: | Tetrazole
N-glycoside
synthesis
hypoglycemic activity
SGLT2 inhibitor |
| Issue Date: | Nov-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Novel tetrazole-bearing N-glycosides have
been designed and synthesized as SGLT2 inhibitors via a conventional protocol starting from substituted phenylacetic
acids and two monosaccharides, d-glucose
and d-galactose, and their
hypoglycemic activity has been tested in
vivo by mice oral glucose tolerance test (OGTT). Two compounds are found to
be more potent than the positive control Dapagliflozin. The structure-activity
relationship has also been investigated. |
| Page(s): | 1499-1508 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(11) [November 2010]
|
|
