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Title: Design, synthesis and <i style="">in vivo</i> hypoglycemic activity of tetrazole-bearing N-glycosides as SGLT2 inhibitors
Authors: Gao, Y L
Zhao, G L
Liu, W
Shao, H
Wang, Y L
Xu, W R
Tang, L D
Wang, J W
Keywords: Tetrazole
hypoglycemic activity
SGLT2 inhibitor
Issue Date: Nov-2010
Publisher: NISCAIR-CSIR, India
Abstract: Novel tetrazole-bearing N-glycosides have been designed and synthesized as SGLT2 inhibitors <i style="">via</i> a conventional protocol starting from substituted phenylacetic acids and two monosaccharides, d-glucose and d-galactose, and their hypoglycemic activity has been tested <i style="">in vivo</i> by mice oral glucose tolerance test (OGTT). Two compounds are found to be more potent than the positive control Dapagliflozin. The structure-activity relationship has also been investigated.
Description: 1499-1508
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(11) [November 2010]

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