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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.47 [2010] >
IJBB Vol.47(5) [October 2010] >
| Title: | Age-associated changes in erythrocyte glutathione peroxidase activity: Correlation with total antioxidant potential |
| Authors: | Maurya, Pawan Kumar
Kumar, Prabhanshu
Siddiqui, Nahid
Tripathi, Preeti
Rizvi, Syed Ibrahim |
| Keywords: | Glutathione peroxidase
Aging
Human
Oxidative stress |
| Issue Date: | Oct-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Oxidative stress is believed to play a central role in aging and
age-associated diseases. It leads to oxidative changes in human red blood cells
(RBCs) in vivo and in vitro. In this study, we evaluated the
oxidative damage to the erythrocytes during aging in the humans using RBC as a
model, by measuring the cytosolic antioxidant enzyme glutathione peroxidase
(GPx) activity. GPx activity was found to be significantly decreased as a
function of human age and positively correlated with total antioxidant
capacity, while negatively correlated with SOD activity. Thus, results of the
present study showed involvement of oxidative stress as one of the risk
factors, which can initiate and/or promote human aging. |
| Page(s): | 319-321 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.47(5) [October 2010]
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