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Title: Performance of CFC free propellant- driven MDI of fluticasone propionate
Authors: Murthy, T E G K
Priya, M Bala Vishnu
Satyanarayana, V
Keywords: Emitted dose;Fluticasone propionate;Metered dose inhalers;Overages;Spray pattern;Valve delivery
Issue Date: Nov-2010
Publisher: NISCAIR-CSIR, India
Abstract: Metered dose inhalers (MDIs) of fluticasone propionate were developed for treatment of asthma and chronic ob¬≠structive pulmonary disease. MDIs with hydrofluoroalkanes based propellants were formulated with various doses, overages and various concentrations of alcohol. Optimum requirements were found as follows: effective valve delivery, overdoses (15%); 100% drug delivery, overages (20%); and emitted dose and fine particle fraction, alcohol content (5-10%).
Page(s): 866-871
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.69(11) [November 2010]

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