NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(11) [November 2010] >


Title: Immunomodulatory effect of Moringa oleifera Lam. extract on cyclophosphamide induced toxicity in mice
Authors: Gupta, Anamika
Gautam, Manish K
Singh, Rahul K
Kumar, M Vijay
Rao, Ch V
Goel, R K
Anupurba, Shampa
Keywords: Amelioration
Cyclophosphamide
Immunomodul-ation
Immunosuppression
Moringa oleifera
Phagocytic index
Issue Date: Nov-2010
Publisher: NISCAIR-CSIR, India
Abstract: Immunomodulatory effect of ethanolic extract (50%) of M. oleifera leaves (MOE) has been studied in normal and immunosuppressed mice models. Different doses of MOE i.e. 125, 250 and 500 mg/kg body weight of mice were administered orally for 15 days. Cyclophosphamide at a dose of 30 mg / kg body weight was administered orally for the next 3 days. On day 16 and 19, hematological parameters like white blood cell (WBC) count, red blood cell (RBC) count, haemoglobin level (Hb), percent neutrophils and organ weight were recorded. Effect of MOE on phagocytic activity of mice macrophages was determined by carbon clearance test. MOE showed significant dose dependent increase in WBC, percent neutrophils, weight of thymus and spleen along with phagocytic index in normal and immunosuppressed mice. The results indicate that MOE significantly reduced cyclophosphamide induced immunosuppression by stimulating both cellular and humoral immunity.
Page(s): 1157-1160
CC License:  CC Attribution- Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.48(11) [November 2010]

Files in This Item:

File Description SizeFormat
IJEB 48(11) 1157-1160.pdf71.96 kBAdobe PDFView/Open
 Current Page Visits: 796 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 576342 since 06-Feb-2009  Last updated on 26-Aug-2014Webmaster: nopr@niscair.res.in