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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(11) [November 2010] >
| Title: | Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats |
| Authors: | Farshid, Amir Abbas
Tamaddonfard, Esmaeal
Yahyaee, Fatere |
| Keywords: | Carrageenan
Histidine
N-acetylcysteine
Neutrophil infiltration
Paw edema |
| Issue Date: | Nov-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The
intra-plantar injection of carrageenan elicited an inflammatory response
characterized by increase of the paw thickness and infiltration of neutrophils
in paw tissues. Histidine, n-acetylcysteine and diclofenac decreased paw
thickness, and neutrophil infiltration in the paw tissues. The
anti-inflammatory effect induced by co-administration of histidine and
n-acetylcysteine with diclofenac, was more than that obtained from histidine
and n-acetylcysteine administered alone. The results suggested that histidine,
n-acetylcysteine and diclofenac produced anti-inflammatory activities by
reducing paw edema and neutrophil infiltrationin induced by carrageenan. Inhibition
of cyclooxygenase products such as prostaglandins may be involved in the
anti-inflammatory effects induced by histidine and n-acetylcysteine. |
| Page(s): | 1136-1142 |
| CC License: |  CC Attribution- Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(11) [November 2010]
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