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Title: Possible role of NO modulators in protective effect of trazodone and citalopram (antidepressants) in acute immobilization stress in mice
Authors: Kumar, Anil
Garg, Ruchika
Gaur, Vaibhav
Kumar, Puneet
Keywords: Anxiety
Oxidative stress
Nitric oxide
Lipid peroxidation
Issue Date: Nov-2010
Publisher: NISCAIR-CSIR, India
Abstract: Stress is an aversive stimulus which disturbs physiological homeostasis and is reflected on a variety of biological systems. The present study was designed to investigate the nitric oxide mechanism in neuroprotective effect of trazodone and citalopram against acute immobilization-induced behavioral and biochemical alteration in mice. Mice were immobilized for a 6 h. Acute immobilization stress caused anxiety, hyperalgesia, impaired locomotor activity and oxidative damage. Pre-treatment with trazodone and citalopram significantly reversed immobilized stress-induced behavioral and biochemical alterations. L-arginine, pretreatment with trazodone or citalopram significantly reversed their protective effects. However, L-NAME or methylene blue pretreatment with trazodone or citalopram significantly potentiated their protective effects alone. Results suggest the involvement of nitric oxide pathways in the protective effect of trazodone and citalopram against immobilization stress induced behavioral and biochemical alterations
Page(s): 1131-1135
CC License:  CC Attribution- Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.48(11) [November 2010]

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