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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(11) [November 2010] >
| Title: | Possible role of NO modulators in protective effect of trazodone and citalopram (antidepressants) in acute immobilization stress in mice |
| Authors: | Kumar, Anil
Garg, Ruchika
Gaur, Vaibhav
Kumar, Puneet |
| Keywords: | Anxiety
Analgesia
Citalopram
Oxidative stress
Nitric oxide
Lipid peroxidation
Trazodone |
| Issue Date: | Nov-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Stress is an aversive stimulus which
disturbs physiological homeostasis and is reflected on a variety of biological
systems. The present study was designed to investigate the nitric oxide
mechanism in neuroprotective effect of trazodone and citalopram against acute
immobilization-induced behavioral and biochemical alteration in mice. Mice were
immobilized for a 6 h. Acute immobilization stress caused anxiety, hyperalgesia,
impaired locomotor activity and oxidative damage. Pre-treatment with trazodone
and citalopram significantly reversed immobilized stress-induced behavioral and
biochemical alterations. L-arginine, pretreatment with trazodone or citalopram
significantly reversed their protective effects. However, L-NAME or methylene
blue pretreatment with trazodone or citalopram significantly potentiated their
protective effects alone. Results suggest the involvement of nitric oxide
pathways in the protective effect of trazodone and citalopram against
immobilization stress induced behavioral and biochemical alterations |
| Page(s): | 1131-1135 |
| CC License: |  CC Attribution- Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(11) [November 2010]
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